suicide inhibitor


Also found in: Medical.

suicide inhibitor

[′sü·ə‚sīd in′hib·əd·ər]
(biochemistry)
A compound which resembles the normal substrate for an enzyme, but which interacts with the enzyme to form a covalent bond and thus inactivates the enzyme.
References in periodicals archive ?
The [alpha]-difluormethylornithine ([alpha]-DFMO), which is the ornithine decarboxylase suicide inhibitor, has been extensively used to study the effects of limiting polyamine synthesis in cell culture and in experimental animals (Poso and Pegg, 1982; Pegg, 1986; Grossie et al., 1987; Kogan and Hagedorn, 2000).
One strategy for circumventing beta-lactamase-mediated resistance has been to combine the beta-lactam drug with a molecule sometimes referred to as a "suicide inhibitor." [4] These molecules bind with the beta-lactamase, preventing it from inactivating the antibiotic.
Non-zinc mediated inhibition of carbonic anhydrases: coumarins are a new class of suicide inhibitors. J Am Chem Soc.