Sulfatase

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sulfatase

[′səl·fə‚tās]
(biochemistry)
Any of a group of esterases that catalyze the hydrolysis of sulfuric esters.

Sulfatase

 

(or sulfohydrolase), any one of several enzymes belonging to the class of hydrolases. Sulfatases catalyze the decomposition of sulfuric esters, with the release of a free sulfation. They are widespread in animals, plants, and microorganisms.

The known sulfatases act on various substrates. Aryl sulfatases hydrolyze aromatic sulfuric esters, glycosulfatases hydrolyze sulfuric esters of monosaccharides and disaccharides, chondrosulfatases decompose chondroitinsulfuric acid, sterol sulfatases hydrolyze steroid sulfuric esters, and cellulose sulfatases split the sulfo group from cellulose polysulfates. Aryl sulfatases have been studied in the greatest detail.

References in periodicals archive ?
A limitation of the flow injection approach is that sulfatase substrates undergo nonenzymatic cleavage to desulfated products in the heated ESI source of the mass spectrometer, which interfere with the activity measurements.
Decreased specific activity of sulfatases was observed only on the 30th day of DM.
Two pathways are important for the local E2 production in target tissues, namely, the "sulfatase pathway," in which biological inactive steroid sulfates are the source for E2, and the "aromatase pathway," in which E2 is derived from androgenic precursors [2].
Expression of novel extracellular sulfatases Sulf-1 and Sulf-2 in normal and osteoarthritic articular cartilage.
Steroid sulfatase activity and expression in mammary myoepithelial cells.
The multiple sulfatase deficiency gene encodes an essential and limiting factor for the activity of sulfatases.
Like P, sulfate esters are cleaved by hydrolytic enzymes called sulfatases to release S[O.sub.4.sup.2-].
For example, sulfatases are being developed for use in enzyme replacement therapy.
An alternative explanation for the enhanced mineralisation of organic S with lower arylsulfatase activity in soils under forest is that the measurement of arylsulfatase activity does not reflect the overall real enzyme activity, since there are several types of sulfatase enzyme present in soil (including arylsulfatases, alkylsulfatases, steroid sulfatases, glucosulfatases, chondrosulfatases, and myrosulfatases) (Tabatabai and Bremner 1970).
MS/MS assays of the sulfatases relevant to the LSDs MPS-II, -IIIA-D, -IVA, and-VI have been reported (68-72).
Biology and function of the reversible sulfation pathway catalysed by human sulfotransferases and sulfatases. Chem Biol Interact 109:3-27.