The reaction, occurring near the collision limit, yields a variety of products, including cysteine sulfenate, sulfinate
and sulfonate anions formed by sequential oxygen atom abstractions, as well as sulfenate radical anions produced by hydroperoxy radical ejection.
Furthermore, urinary excretion of taurine-related metabolites (hypotaurine, cysteine sulfinate
, cysteine, and cystathionine) was significantly higher with AA-MF compared to GMP-MF (Figure 3).
Ma et al., "Arene control over thiolate to sulfinate
oxidation in albumin by organometallic ruthenium anticancer complexes," Chemistry-A European Journal, vol.
The main sulphur-compound is S- benzyl phenylmethane thiosulfinate (called Petivericine) and other isolates that include s-benzyl (2-hydroxyl) ethane thiosulfinate, S - (2 - hydroxyethyl) phenylmethane thiosulfinate, and S- (2-hydroxyethy) 2- (hydroxyethane) thio sulfinate
desulfinase, a NIFS-like protein of Escherichia coli with selenocysteine lyase and cysteine desulfurase activities.
Recently, benzothiazole sulfinate
(BTS), a water-soluble S[O.sub.2] donor, was reported to exhibit slow and pH-dependent S[O.sub.2] release ability in aqueous solutions.
We observed a significant decrease in mRNAs encoding the taurine biosynthetic enzymes cysteine dioxygenase (CDO) and cysteine sulfinate
decarboxylase (CSD), the rate-limiting enzyme for the conversion of cysteine to taurine (Bitoun and Tappaz 2000a, 2000b), in the livers of TCDF-treated [Ahr.sup.+/+] mice (Figure 4I).
Tappaz, "Molecular cloning and sequence analysis of the cDNA encoding rat liver cysteine sulfinate
decarboxylase (CSD)," Biochimica et Biophysica Acta, vol.
The sulphur atom within cysteine can exist as a reduced thiol (SH) or in different oxidized states, such as thiolate anion ([S.sup.-]), sulfenate (S[O.sup.-]), disulfide (S-S) sulfinate
(S[O.sub.2.sup.-]), or sulfonate (S[O.sub.3.sup.-]) .
The linkage between the two sulfur atoms is quite labile and tends to exchange with free thiols to generate a disulfide bond leaving sulfite or sulfinate
. An interesting feature of these reactive groups is the reversibility of the disulfide bond they generate, which is different from the highly stable thioether bond.
Condensation of 2-bromo-1-(4-(methylsulfonyl)phenyl)ethanone 32 and 4-methyl sodium benzene sulfinate
33 gave 1-(4-(methylsulfonyl)phenyl)-2-tosylethanone 34.
The first step of the reaction with both is an addition reaction to give different intermediates 9 and 10, 9 is then protonated to give the vinylic thioether 11 whereas the intermediate 10 eliminates the sulfinate
anion to 11 (Scheme-2).