Sulfone

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sulfone

[′səl‚fōn]
(organic chemistry)
R2SO2(or RSOOR) A compound formed by the oxidation of sulfides, for example, ethyl sulfone, C4H10SO2, from ethyl sulfide, C4H10S; the use of sulfones, particularly 4,4′-sulfonyldianiline (dapsone) in the treatment of leprosy leads to apparent improvement; relapses associated with sulfone-resistant strains have been encountered.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Sulfone

 

any of several organosulfur compounds containing the

group bonded to two organic radicals. Sulfones are colorless and very stable crystalline substances; for example, diphenylsulfone, (C6H5)2SO2, melts at 128°C and boils at 379°C. Both aliphatic and aromatic sulfones are obtained by oxidation of organic sulfides; aromatic sulfones are also obtained by means of the Friedel-Crafts reaction.

Some substituted sulfones are used in medicine—for example, diaphenylsulfone (4,4’-diaminodiphenylsulfone) is used in the treatment of leprosy. Polyarylenesulfones are used for the production of packages for foodstuffs and electrotechnical parts.

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
Toxic effects of diamino diphenyl sulphone in leprosy.
Samples of para and meta aminophenyl-Psulphatoethyl sulphone were generously provided by BASF.
Further, its operations are supported by backward integration for key dye intermediates, mainly H-Acid and Vinyl Sulphone.
A variety of polymers was considered for insulation systems including polysulphone, polyether sulphone, polyurea, five-layer PP foam, polyamide thermal barrier and fivelayer PP, HT rubber, syntactic phenolic foam and syntactic epoxy with a PU outer insulation layer.
Success by others in identifying two sulphone compounds (V147, V186) with potential therapeutic effect in experimentally infected animals heralded the need for clinical trials in humans.
Sulpha medications (SMZ and dapsone, a sulphone) interfere with folate synthesis by competitively inhibiting the enzyme dihydropteroate synthase (DHPS) encoded by the folic acid synthase (FAS) gene, a multifunctional gene that also encodes dihydroneopterin aldolase and hydroxymethyldihydropterin pyrophosphokinase (5).
Pesticide (aldicarb sulphoxide, aldicarb sulphone, demeton-S-methyl sulphoxide, carbendazim, methomyl, thiabendazole, methiocarb sulphoxide, methiocarb sulphone, aldicarb, imazalil, thiodicarb, phorate sulphoxide, phorate sulphone, methiocarb) standard substances were obtained from Dr.
The chloroform layer was evaporated and the product of this reaction was identified as diphenyl sulphone.
Sikament-FF-N naphthalene formaldehyde sulphone) was the superplasticizer used, and technical information given is as follows: pH 9, liquid, density 1.22 kg/l, proposed amount of cement weight 0.8-3.0% (Table 2).
TAA is bioactivated by CYP450 and/or flavin containing monooxygenase systems to toxic metabolites TAA sulfine (sulphoxide) and sulfene (sulphone), which produce centrilobular hepatic necrosis and apoptosis (Dogru-Abbasoglu et al., 2001).
Each filtration module within the ultra-filtration plant is constructed from hydrophilic polyether sulphone hollow fibres, this structure effectively guarantees high levels of physical and chemical stability.
Today, most people who suffer from Hansen s Disease are treated as outpatients with sulphone drugs, which became available in 1947.