Sydney Brenner

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Brenner, Sydney,

1927–2019, British molecular biologist, Ph.D. Oxford, 1954. He was director of the MRC Laboratory of Molecular Biology in Cambridge, England (1979–86), and director of the MRC Molecular Genetics Unit (1986–91) before founding (1996) the Molecular Sciences Institute, Berkeley, Calif. In 2000 he became a distinguished research professor at the Salk Institute, La Jolla, Calif. For many years he also played a leading role in developing molecular biology research in Europe and Singapore. In 2002, with H. Robert HorvitzHorvitz, H. Robert
(Howard Robert Horivtz), 1947–, American geneticist, b. Chicago, Ill., Ph.D. Harvard, 1974. Horvitz has been a professor at the Massachusetts Institute of Technology since 1978.
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 and John E. SulstonSulston, Sir John Edward,
1942–2018, British molecular biologist, Ph.D. Cambridge, 1966. He was staff scientist at the MRC Laboratory of Molecular Biology in Cambridge, England, from 1969 to 1992, when he became founding director (until 2000) of what is now the Wellcome
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, Brenner received the Nobel Prize in Medicine or Physiology for discoveries relating to the genetic regulation of organ development and programmed cell death. Brenner is credited with laying the foundation for the work by establishing the nematode Caenorhabditis elegans as a model organism for genetic studies. The .04-in.-long (1-mm) worm has a short life cycle, allowing researchers to learn substantial information about organ development and cell death in a relatively short period of time, and it is transparent, enabling cell division to be observed directly under a microscope. Brenner demonstrated that a chemical compound could induce gene mutations in the nematode and that different mutations could be tied to specific genes. Earlier, Brenner had shown that triplets of nucleotides were the basis of DNA coding and with Francis CrickCrick, Francis Harry Compton,
1916–2004, English scientist, grad. University College, London, and Caius College, Cambridge. Crick was trained as a physicist, and from 1940 to 1947 he served as a scientist in the admiralty, where he designed circuitry for naval mines.
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 and others had decoded how amino acids were produced from DNA; at the same time, he also participated in discovery of messenger RNA, the means by which the information in DNA is conveyed to the cell organelles that produce proteins.


See his autobiography (2001).

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References in periodicals archive ?
The late Nobel laureate Sydney Brenner addressed these questions in a year-long lecture series in 2017 that took us on a 14-billion-year scientific odyssey through cosmology, chemistry, biology, paleontology, archaeology, anthropology and sociology.
Sydney BRENNER, Honorary Member, had passed away on April 5, 2019; the members expressed their profound sense of grief in silence.
* Sydney Brenner, a Nobel Prize-winning biologist who helped decipher the genetic code, has died.
SINGAPORE, Apr 5, 2019 - (ACN Newswire) - It is with deep regret that the Agency for Science, Technology and Research (A*STAR) announces the passing of Dr Sydney Brenner, Honorary Singapore Citizen, and A*STAR Senior Fellow, early this morning.
It was almost 50 years ago that the Cambridge-based geneticist Sydney Brenner pioneered the use of C.
Horvitz shared the 2002 Nobel Prize in Physiology or Medicine with Sydney Brenner and John Sulston.
Nobel Laureate Sydney Brenner who also suggested the formation of HUGO, delivered a keynote lecture on Reading the Human Genome.
of Texas Southwestern Medical Center at Dallas) presents this fascinating biography of Sydney Brenner, one of the heroes of molecular biology.
Sydney Brenner, Francois Jacob and Matthew Meselson show that messenger RNA (above) carries the information required to make proteins.
He graduated in 1950, always claiming this to have been the greatest Wits graduating class ever, with such notable names as Philip Tobias, Sydney Brenner and Priscilla Kincaid-Smith.

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