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Having the ability to produce physiologic changes similar to those caused by action of the sympathetic nervous system.



a pharmacological substance whose action basically coincides with the effects of the excitation of the sympathetic nervous system, including the constriction of blood vessels and the dilatation of bronchi. Inasmuch as sympathomimetics act on adrenergic receptors, that is, on receptor formations sensitive to norepinephrine and adrenaline, they are conventionally called adrenomimetics.

Sympathomimetics may be direct or indirect. Direct sympathomimetics act directly on adrenergic structures; they include norepinephrine, adrenaline, and Adrianol (also called sympa-thol). Indirect sympathomimetics either promote the release or block the capture of a mediator; they include Tyramine, Phena-mine (also called amphetamine), ephedrine, and imizin (also called imipramine). Indirect sympathomimetics cause the quantity of a mediator to increase and thereby produce sympathomimetic effects.

In clinical practice adrenaline, norepinephrine, and Adrianol are used locally to constrict blood vessels during hemorrhaging. They are also used to increase arterial pressure in cases of collapse. Ephedrine is used to arrest asthma attacks and to constrict peripheral vessels (for example, it is applied directly to the nose in cases of a cold). Phenamine is characterized by peripheral sympathomimetic action—for example, it constricts blood vessels and increases systole. It also exerts a stimulating effect on the central nervous system and consequently is used to excite nervous activity. Imizin is pharmacologically an antidepressant and is therefore used in the treatment of nervous and mental disorders accompanied by depression.


Zakusov, V. V. Farmakologiia, 2nd ed. Moscow, 1966.
Anichkov, S. V. Izbiratel’noe deistvie mediatornykh sredstv. Leningrad, 1974.
Goodman, L. S., and A. Gilman. The Pharmacological Basis of Therapeutics, 3rd ed. New York-London-Toronto, 1965.


References in periodicals archive ?
While studies are present indicating that phenylethylamine group drugs should not be used for the purpose of premature labour arrest due to their sympathomimetic and cardiovascular side effects, other studies also state that the cardiovascular side effects of IP are minimal.
10) With this in mind and the fact that the medical fraternity seems to be particularly vulnerable to stimulant use, the aim of this study was to determine the prevalence and correlates of non-medical sympathomimetic use as well as subjective opinion on peer numbers using these drugs and university's attitude towards this use among a sample of undergraduate medical students at a South African university.
Patients with extreme sympathomimetic syndrome, hallucinations, and violent behavior may have taken one of many possible synthetic cathinones.
Administration of sympathomimetic drugs is the most effective method for maintaining blood pressure and tissue perfusion during anesthesia in horses.
Therapy was changed to the cardio-selective betaxolol or the sympathomimetic agent dipivefrin.
Sympathomimetics such as pseudoephedrine are found under brand names such as Sudafed and can be taken orally.
The patient failed to respond to repeated injections of appropriate doses of sympathomimetics, but did respond to high-dose catecholamine infusions.
This is seen most commonly with amphetamine and cocaine, but may also occur with several less potent drugs, including over-the-counter sympathomimetics.
Denervation supersensitivity with intact nerve terminals at the iris dilator muscle, as evidenced by preserved responsiveness to indirectly acting sympathomimetics (see above), would be consistent with preganglionic or central deficit.