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Having the ability to produce physiologic changes similar to those caused by action of the sympathetic nervous system.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.



a pharmacological substance whose action basically coincides with the effects of the excitation of the sympathetic nervous system, including the constriction of blood vessels and the dilatation of bronchi. Inasmuch as sympathomimetics act on adrenergic receptors, that is, on receptor formations sensitive to norepinephrine and adrenaline, they are conventionally called adrenomimetics.

Sympathomimetics may be direct or indirect. Direct sympathomimetics act directly on adrenergic structures; they include norepinephrine, adrenaline, and Adrianol (also called sympa-thol). Indirect sympathomimetics either promote the release or block the capture of a mediator; they include Tyramine, Phena-mine (also called amphetamine), ephedrine, and imizin (also called imipramine). Indirect sympathomimetics cause the quantity of a mediator to increase and thereby produce sympathomimetic effects.

In clinical practice adrenaline, norepinephrine, and Adrianol are used locally to constrict blood vessels during hemorrhaging. They are also used to increase arterial pressure in cases of collapse. Ephedrine is used to arrest asthma attacks and to constrict peripheral vessels (for example, it is applied directly to the nose in cases of a cold). Phenamine is characterized by peripheral sympathomimetic action—for example, it constricts blood vessels and increases systole. It also exerts a stimulating effect on the central nervous system and consequently is used to excite nervous activity. Imizin is pharmacologically an antidepressant and is therefore used in the treatment of nervous and mental disorders accompanied by depression.


Zakusov, V. V. Farmakologiia, 2nd ed. Moscow, 1966.
Anichkov, S. V. Izbiratel’noe deistvie mediatornykh sredstv. Leningrad, 1974.
Goodman, L. S., and A. Gilman. The Pharmacological Basis of Therapeutics, 3rd ed. New York-London-Toronto, 1965.


The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
It has a sympathomimetic effect and is 40 times more spasmolytic than papaverine.3,4 It is used in the treatment of Raynaud's phenomenon in human medicine and its primary use is to prevent pre-term labour and tocolysis.5 In 1961, the first beta adrenergic agonist drug to be used in tocolysis was IP.6 In 1965, Devries and Wilson stated that IP could be used in cattle and sheep for uterus relaxation in various obstetric situations such as, simple dystocia, embryotomy and caesarean section (CS).2 In veterinary practice today, it is used especially in the treatment of equine navicular disease and laminitis.
Of the students, 42 (17%) reported a lifetime use of sympathomimetics for non-medical purposes and 33 of this group (79%) reported use within the past year.
These include eosinophilic cystitis, herpes simplex virus (HSV) infection, epidural anaesthesia, anti-cholinergic or sympathomimetic agents, urinary tract infection (UTI), and postpartum, postoperative and psychogenic causes (Table 3).
Despite structural similarities to other sympathomimetic amines (Fig.
Administration of sympathomimetic drugs is the most effective method for maintaining blood pressure and tissue perfusion during anesthesia in horses.
Ethanol and caffeine are probably the most prominent of these, but physicians should carefully question patients about other possible causes, including cocaine, nicotine, sympathomimetics, chlorpromazine, erythropoietin, oral contraceptives, cyclosporine, tricyclic antidepressants, MAO inhibitors, and certain herbal supplements, such as the Chinese stimulant ma huang (ephedrine).
* Parenteral agents (methyxanthines and sympathomimetics) are not as effective and have potential adverse effects (B).
The mechanism of action whereby agents such as nitrous oxide, neuroleptics, antihistamines, sympathomimetics, amphetamines and corticosteroids produce specific analgesia have yet to be defined.
Treatments free from the respiratory side-effects of [Beta]-antagonists include sympathomimetics. Topical adrenaline and the adrenaline precursor dipivefrin lower IOP They probably act on pre-synaptic [Alpha]-2 adrenoceptors on the ciliary body [21].
Analgesics, antacids, anticholinergics, antidepressants, sympathomimetics, antipsychotics, iron, calcium, bismuth and zinc salts, sucralfate, laxative abuse, phenytoin, diuretics, antidiarrheals, colestipol, cholestyramine.