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The analysis of the individual lymphocyte subpopulations showed increased global DNA methylation in B-cells (Figures 4(c) and 4(d)), T-helper cells and T-cytotoxic cells (Figures 4(e) and 4(f)), suggesting that obesity is associated with altered epigenetic signature in specific subpopulations of circulating lymphocytes.
We observed a global DNA hypermethylation in B-cells and T-helper and T-cytotoxic cells, consistent with our recent findings in B-cells from obese individuals [14].
T-cytotoxic cells and antibodies can induce perforations of different size and quantities on somatic cells surface, which can formed the precancerous and later the cancer cells arising.