substance P

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substance P

[′səb·stəns ′pē]
(biochemistry)
An undecapeptide widely distributed in the central nervous system and found in highest concentrations in superficial layers of the dorsal horn of the spinal cord, in the trigeminal nerve nucleus, and in the substantia nigra; acts as a neurotransmitter.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
In a series of experiments, the team assessed pain response in two groups of mice -- one with intact Tac1 neurons and another with chemically disabled Tac1 neurons.
Ong et al., "Serum methylation levels of TAC1 SEPT9 and EYA4 as diagnostic markers for early colorectal cancers: a pilot study," Biomarkers, vol.
identified increased methylation of TAC1, SEPT9, and NELL1 genes in serum to be correlated to poor prognosis in colorectal cancer in a cohort of 150 patients [63].
Interestingly, many modules identified here including TAC1 and TTR,are implicated in some sensory-related activities during early development for subgroup 3 (Figure 4(c)).
Biological actions of TAC1 and TAC3 are mediated by three types of G protein-coupled receptors (TACR1, TACR2, and TACR3).
In addition, many inflammatory response-related genes such as C1QA, C1QB [127], TAC1 [128, 129], TGFBR1 [129], and TGM2 [130] have been associated with schizophrenia.
Substance P and neurokinin A are closely related neurotransmitters and are both encoded by the same Tac1 gene.
serum samples were taken from patients to the tubes for the measurement of TAC, TOC, PON at the application (TAC1, TOC1, PON), TAC2, TOC2, PON II at the 48th hours and TAC3, TOC3, PON III at the 6th week.