Moreover, the gene expression profile of proximal tibia MAT is correlated with elevated beige adipocyte markers (Ucp1, HoxC9, Prdm16, Tbx1
, and Dio2) compared with distal MAT, indicating the space-specific interaction between MAT and bone remodeling .
regulate specification of prosensory patches .
The gene expression of markers specifically indicating induction of brown adipocyte differentiation ("browning") was investigated and was completely negative for the marker genes UCP1, TMEM26, CD136, and TBX1
Mutations in NKX2-5 (5q35.1), GATA4 (8q23.1), ZFPM2 (8q23.1), GATA6 (18q11.2), GDF1 (19p13.11), JAG1 (20p12.2), and TBX1
(22q11.21) have been reported in sporadic cases with tetralogy of Fallot; however, interaction of these genes and FMR1 gene has never been reported .
Detecting 22q11.2 deletion in Chinese children with conotruncal heart defects and single nucleotide polymorphisms in the haploid TBX1
DiGeorge syndrome, Tbx1
, and retinoic acid signaling come full circle.
Deletion of a small chromosome gene TBX1
causes tetralogy of Fallot.
The result showed that five candidate genes, including T-box protein 1 (TBX1
), transcription factor 21 (TCF21), adiponectin (APN), tumor necrosis factor-alpha (TNF-[alpha]), and monocyte chemotactic protein 1 (MCP-1), were all expressed in the visceral adipose tissue of normal, obesity, and T2DM individuals in Uygur population.
also binds to the DNA sequence as a dimer, whereas TBX2 appears to bind to the same DNA sequence as a monomer .
In humans, mutations in 25 different homeobox transcription factors have been found in patients with congenital heart disease (McCulley and Black 2012); expression of 14 of these (Cited2, Ets1, Foxh1, Gata4, Gata6, Handl, Hand2, Hoxal, Irxl, Nkx2-5, Nkx2-6, Pitx2, and Tbx1
) was disrupted by TCDD in our mouse ES cell differentiation experiments.