TNF


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TNF

(organic chemistry)
References in periodicals archive ?
D-GalN (1 mg/ml) and TNF (100 ng/ml) were used to induce Hepa1-6 cells to apoptosis; and Hochest 33342 staining was applied to detect the cell apoptosis (14).
Genetic variation in the TNF gene is associated with susceptibility to severe sepsis, but not with mortality.
TNF tolerance was first described in rats and mice on the basis of reduced physiological responsiveness towards a subsequent stimulation with TNF following a repeated application of sublethal doses of this cytokine within a certain time period [2, 8].
Molecular cloning, characterization, and expression of TNF cDNA and gene from Japanese flounder Paralychthysolivaceus.
Our result is not compatible with a study conducted on RA patients, which showed that GG genotype was associated with higher serum TNF levels than GA genotype.
Furthermore, to improve therapeutic efficacy and patient safety, a rational, laboratory-based approach is provided to aid the management of patients on TNF antagonists.
Ng et al., "Successful tumour necrosis factor (TNF) blocking therapy suppresses oxidative stress and hypoxia-induced mitochondrial mutagenesis in inflammatory arthritis," Arthritis Research and Therapy, vol.
In chronic liver cell damage in patients with chronic hepatitis, TNF alpha is secreted by macrophages, inflammatory cells and damaged hepatocytes in the liver and plays a role in the apoptosis of hepatocytes.
TNF induces caspase-dependent inflammation in renal endothelial cells through a Rho- and myosin light chain kinase-dependent mechanism.
In the last years, TNF antagonists such as infliximab (IFX), adalimumab (ADA), etanercept, golimumab, certolizumab have revolutionized the treatment of autoimmune inflammatory diseases and were authorized for the treatment of cutaneous psoriasis.