TNF


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TNF

(organic chemistry)
References in periodicals archive ?
These data indicate that vedolizumab is an effective therapeutic option for ulcerative colitis and it potentially has a better effect in biologic-nave patients, compared to those who have previously failed a TNF antagonist.
CTL is responsible both for breakdown of infected cells and for TNF alpha and IFN gamma production (14,15).
For patients with active enthesitis, dactylitis, or both and an insufficient response to an NSAID or local glucocorticoid injections, then a TNF inhibitor or alternatively an IL-12 and IL-23 inhibitor (currently ustekinumab) or an IL-17 inhibitor (currently secukinumab) may be considered.
The pathogenic mechanism remains actually unknown, but there is the hypothesis of a difference between the interferon [alpha],he TNF and plasmacytoid cell proliferation.
Crucial role of TNF receptor type 1 (p55), but not of TNF receptor type 2 (p75), in murine toxoplasmosis.
It remains unclear whether this was a real effect of the anti-TNF drugs, or a bias to treat patients with lower CV disease risk with a TNF blocker, he said.
Impact of the -308 TNF promoter polymorphism on the transcriptional regulation of the TNF gene: relevance to disease.
This is really the first mechanism showing how TNF can turn inflammation down," he said.
TNF synthesis by blood-derived mononuclear cells from MS patients increases prior to onset of exacerbations as compared with other times.
Adalimumab (Humira) is an IgG monoclonal antibody specific for TNF-alpha, thereby blocking its interaction with cell surface TNF receptors.
Thousand Oaks, CA) has patented DNA sequences coding for a TNF-binding protein and for the TNF receptor of which this protein constitutes the soluble domain.