In 2004, the European Haemovigilance Network (EHN) proposed criteria for the diagnosis of TRALI
, which is summarized in Table 1.
is a rare but known complication of FFP, and there was not an alternative explanation as likely as TRALI
to explain the cause of death.
These include allergic reactions, transfusion-related acute lung injury (TRALI
), haemolysis, fluid overload and infectious complications.
In addition to infectious risk, it is associated with transfusion-related acute lung injury (TRALI
), which has significant morbidity and mortality.
13 (30) HTR 12 (27) TACO 12 (27) Microbial infection 5 (11) Anaphylaxis 1 (2) Hypotensive reaction 1 (2) Abbreviations: CBER, Center for Biologics Evaluation and Research; HTR, hemolytic transfusion reaction; TACO, transfusion-associated circulatory overload; TRALI
, transfusion-related acute lung injury.
Plasma transfusions can contribute to adverse outcome by causing transfusion-related acute lung injury (TRALI
), a serious life-threatening and underreported complication of allogeneic blood transfusions.
Abrupt onset of hypoxaemia (pulse oximetry less than 90 percent on air), and pulmonary oedema without evidence of circulatory fluid overload, may indicate TRALI
. Often this is accompanied by dyspnoea, fever, hypotension and tachycardia.
Transfusion-related acute lung injury (TRALI
): current concepts and misconceptions.
Other immune-mediated complications include allergic reactions, febrile reactions, transfusion-related acute lung injury (TRALI
), graft-versus-host disease (GVHD), anaphylaxis and haemolysis.
There's a newly detected injury to the lungs called TRALI
(transfusion-related acute lung injury) that seems to be caused by immune cells in women who have been pregnant.
Edema pulmonar Secundario a hipervolemia Reacciones transfusionales al plasma Fiebre, broncoespasmo, hipotension, dolor toracico, arritmias cardiacas, TRALI
La plasmaferesis se debe iniciar tan pronto como se sospecha la PTT ya que retrasos en el tratamiento aumentan la mortalidad.