influence interdigestive rhythm and contractile strength of human small intestine," Digestive Diseases and Sciences, vol.
Maggi, "Substance P activates responses correlated with tumour growth in human glioma cell lines bearing tachykinin
NK1 receptors," British Journal of Cancer, vol.
* Phyllomedusin - a tachykinin
which affects the salivary glands, tear, ducts, intestines, and bowels; it contracts the smooth muscles, and contributes to the violent purging
No predicted differences in neurotransmitter levels were observed, the researchers said, but they did note disruption in the Tachykinin
receptor 1 gene.
The SP is an 11-amino-acid neuropeptide member of the tachykinin
family, which localizes in the central nervous system, enteric nerves, immune cells and sensory neurons.
Kirschner, "Neurotrophic and neurotoxic effects of amyloid [beta] protein: reversal by tachykinin
neuropeptides," Science, vol.
Motilin, a 22-amino acid residue polypeptide secreted by endocrine M cells, has a powerful fundic pouch motor-stimulating activity [11, 12], and SP, a member of tachykinin
family of neuropeptides widely distributed throughout the central nervous system (CNS), controls the enteric noncholinergic motor inhibition of the fundus .
Another sensory neuropeptides neurokinin A (NKA, one of the tachykinin
) and secretoneurin (generated by proteolysis of chromogranins) are present in the rat and human corneas [25, 26].
Calixto, "Further evidence for the involvement of tachykinin
receptor subtypes in formalin, and capsaicin models of pain in mice," Neuropeptides, vol.
Moreover, maternal smoking has been shown to alter the expression of genes related to neuropeptide signaling and signal transduction, as well as development, particularly tachykinin
3 (TAC3), left-right determination factor 2 (LEFTY2), heparin-binding EGF-like growth factor (HBEGF), mitochondrial fission factor (MFF), and fibulin1 (FBLN1), via mechanisms possibly related to genome-wide changes in DNA methylation .
SR142801 behaves as a tachykinin
NK-3 receptor agonist on a spinal nociceptive reflex in the rat.
NK1 receptor antagonists act centrally to inhibit emesis induced by the chemotherapeutic agent cisplatin in ferrets." Neuropharmacology 35.8 (1996): 1121-1129.