taxol


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taxol

[′tak‚sōl]
(pharmacology)
C47H51NO14 An alkaloid derived from the Pacific yew tree (Taxus brevifolia) that is used in the treatment of ovarian and breast cancer.
References in periodicals archive ?
Tree that they named "Taxol." (3) Taxol exhibited potent
"This ensures the taxol, kept inside the core of this delivery system, reaches the site of the tumour.
The nano-medicine performed well in healing breast tumors in animals, he said, adding the results suggest that the product can also reduce the side effects and increase taxol dissolution.
Posteriormente, el taxol fue producido semisinteticamente a partir de los precursores tales como: baccatina III y 10 diacetil baccatina III aislados de las agujas y otras especies de Taxus spp.
After tumor establishment, mice were divided into experimental groups (n= 7 per group) each treated with one of the following substances/combinations: Taxol (20mg/kg bw), R848 (60mg/kg bw), LPS (2mg/kg bw), Irinotecan (20mg/kg bw), Taxol + R848, Taxol + LPS, and R848 + LPS.
The FDA said it based the new approval on the previous approval of Taxol for this indication and a supportive study.
When the patent for Taxol expired, it became open to generic competition.
Originally isolated from the bark of the Pacific Yew tree, Taxol is a drug used to treat a variety of cancers, including lung and breast.
Contributors from pharmaceutical companies and universities in Europe, North America, and China consider such topics as homoharringtonine and related compounds, taxol and its analogs, novel anti-tumor agents from Dolabella auricularia, biochemical and biological evaluation of (+)-CC-1065 analogs and conjugates with polyamides, and staurosporines and structurally related indolocarbazoles as anti-tumor agents.
Susan Mooberry, Ph.D., leader of the Experimental Development Therapeutics Program at the Cancer Therapy and Research Center and a professor of pharmacology in the School of Medicine at the UT Health Science Center, has been working to isolate substances in the plant, looking for a plant-derived cancer drug with the potential of Taxol.
During the study patients were infused with either 250 mg/m2 of Paclical or with 175 mg/m2 of Taxol of US Bristol-Myers Squibb (NYSE:BMY).