He pointed out that in two animal studies that do show positive results for a specific cardiac teratogen
, the research does not reflect appropriate dose response relationships (J.
Isotretinoin (Accutane) may be the most potent teratogen
available; the effects of exposure during pregnancy involve the central nervous system, the head and face, cardiovascular system, and thymus.
It is not an animal teratogen
, and we have not seen any clustering of or increase in birth defects.
Methimazole is a known teratogen
associated with this condition hence should be avoided in pregnancy.
As with all teratogens
, the toxicity is dose related.
Clearly, there is a gap between current and optimal practice when teratogens
are prescribed to women of reproductive age.
This is why it was important to develop a model encompassing both cell differentiation and migration that would give researechers a more complete and accurate picture of the effects of teratogens
on the developing embryo.
(agents known to cause birth defects) include certain medications, such as thalidomide (used in patients with leprosy), isotretinoin (used to treat severe acne), valproic acid (used to treat seizures), methotrexate (used to treat psoriasis, rheumatoid arthritis, and cancer), and mycophenolate mofetil (used in transplant recipients) used during pregnancy; maternal infections, such as rubella and varicella during pregnancy; maternal conditions, such as poorly controlled pregestational diabetes; and smoking or alcohol use during early pregnancy (6).
rerio embryos when exposed to teratogens
. Similarly, in the present study, tail malformation such as bent tail, hook-like, and twisted tail (Fig 5 C, D, G) was the most marked morphological endpoint of embryos when exposed to the extracts of both C.
They are multifactorial, maternal as well as paternal, but universally associated with environmental teratogens
. (7) Good nutritional assessment and counseling is a critical component of preconceptional care.
They suggested that "potential teratogens
"--particularly benzene and polycyclic aromatic hydrocarbons--emitted from the wells, related infrastructures, or drilling processes could be a causal factor related to the health effects.
In the first presentation of the National Pregnancy Registry for Atypical Antipsychotics at an annual meeting in June, my coinvestigators and I concluded that atypical antipsychotics are unlikely to be major teratogens
, like valproic acid.