tetrahydrofolic acid

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tetrahydrofolic acid:

see coenzymecoenzyme
, any one of a group of relatively small organic molecules required for the catalytic function of certain enzymes. A coenzyme may either be attached by covalent bonds to a particular enzyme or exist freely in solution, but in either case it participates intimately in
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References in periodicals archive ?
The basic mechanism of pyrimethamine against malaria is to target on folic acid which produces tetrahydrofolates by inhibiting the enzyme dihydrofolate reductase (DHFR) (Yuvaniyama et al.
Leucovorin provides a source of the tetrahydrofolates that are depleted by methotrexate's inhibition of dihydrofolate reductase, but methotrexate competes with leucovorin for cell uptake.
Common Mutation in the Methylenetetrahydrofolate Reductase Gene is Associated with an Accumulation of Formylated Tetrahydrofolates in Red Blood Cells.
Many biomolecules undergo autooxidation reaction on contact with [O.sub.2] producing ROS, for example catecholamines, tetrahydrofolates and reduced reduced flavins react directly with [O.sub.2] to form [O.sub.2.sup.-.] (8) Several sugars, including glucose, react with proteins to produce oxygen radicals.
The folic acid analog methotrexate (MTX) [1] inhibits the enzyme dihydrofolate reductase (DHFR; EC 1.5.1.3.), thus depleting cells of chemically-reduced tetrahydrofolates, which are cofactors in the biosynthesis of the purine and pyrimidine nucleotide precursors of DNA.