Tetrahydrofolates | Article about Tetrahydrofolates by The Free Dictionary
tetrahydrofolic acid (redirected from Tetrahydrofolates)
Also found in: Medical
tetrahydrofolic acid: see coenzymecoenzyme
, any one of a group of relatively small organic molecules required for the catalytic function of certain enzymes. A coenzyme may either be attached by covalent bonds to a particular enzyme or exist freely in solution, but in either case it participates intimately in
..... Click the link for more information. .
References in periodicals archive
thus depleting cells of chemically-reduced tetrahydrofolates
, which are cofactors in the biosynthesis of the purine and pyrimidine nucleotide precursors of DNA.
Leucovorin provides a source of the tetrahydrofolates
that are depleted by methotrexate's inhibition of dihydrofolate reductase, but methotrexate competes with leucovorin for cell uptake.
A common mutation in the methylenetetrahydrofolate reductase gene is associated with an accumulation of formylated tetrahydrofolates
in red blood cells.