tetrahydrofolic acid

(redirected from Tetrahydrofolates)
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tetrahydrofolic acid:

see coenzymecoenzyme
, any one of a group of relatively small organic molecules required for the catalytic function of certain enzymes. A coenzyme may either be attached by covalent bonds to a particular enzyme or exist freely in solution, but in either case it participates intimately in
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References in periodicals archive ?
thus depleting cells of chemically-reduced tetrahydrofolates, which are cofactors in the biosynthesis of the purine and pyrimidine nucleotide precursors of DNA.
Leucovorin provides a source of the tetrahydrofolates that are depleted by methotrexate's inhibition of dihydrofolate reductase, but methotrexate competes with leucovorin for cell uptake.
A common mutation in the methylenetetrahydrofolate reductase gene is associated with an accumulation of formylated tetrahydrofolates in red blood cells.