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A hereditary form of hemolytic anemia resulting from a defective synthesis of hemoglobin: thalassemia major is the homozygous state accompanied by clinical illness, and thalassemia minor is the heterozygous state and may not have evident clinical manifestations. Also known as Mediterranean anemia.



(also thalassanemia), a familial hemolytic anemia, first detected in 1925 among inhabitants of the Mediterranean region. Thalassemia is caused by disturbances in hemoglobin synthesis.

References in periodicals archive ?
To a question he said if two thalassaemia minor get married to each other, 25 % chances are there that their kid is going to born with thalassaemia major.
He said thalassaemia minors are people who carry one defective gene of thalassaemia.
HYDERABAD, May 02, 2009 (Balochistan Times) -- Thalassaemia major is a deadly blood disorder and one of the most common genetic diseases in Pakistan and there are approximately 12 million carriers of Thalassaemia minor gene in Pakistan and an estimated 5,000 children are born annually with Thalassaemia major.