Thalassemia

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Related to Thalassaemias: thalassemia, Thalassaemia minor, thalassemic

thalassemia

[‚thal·ə′sē·mē·ə]
(medicine)
A hereditary form of hemolytic anemia resulting from a defective synthesis of hemoglobin: thalassemia major is the homozygous state accompanied by clinical illness, and thalassemia minor is the heterozygous state and may not have evident clinical manifestations. Also known as Mediterranean anemia.

Thalassemia

 

(also thalassanemia), a familial hemolytic anemia, first detected in 1925 among inhabitants of the Mediterranean region. Thalassemia is caused by disturbances in hemoglobin synthesis.

References in periodicals archive ?
The study was conducted at the COMSATS Institute of Information Technology (CIIT), Sahiwal, Pakistan, from October 2012 to October 2013, and comprised families having affected children by thalassaemia and autosomal recessive b-thalassemia.
With its high prevalence, thalassaemia is causing an increasingly severe public health burden for many countries in Southeast Asia.
Among the tribal population, there are no studies regarding the prevalence of sickle anaemia and thalassaemia in tribal community of Lambadas in Warangal district of Telangana state.
This study was conducted to investigate the prevalence of sickle cell anaemia and thalassaemia among Lambada tribes of Warangal district.
Conclusion: It is concluded that the frequency of iron deficiency is more common in age under 5 as compared to thalassaemia trait.
Key words: Thalassaemia, iron deficiency anaemia, children.
Interacting [alpha][degrees] thalassaemia may sometimes normalize the RBC indices but the HbA2 levels are generally not significantly reduced.
2,3,4,5) The clinical spectrum of the disorders varies from asymptomatic conditions to serious disorders like Thalassaemia major and sickle cell disease that requires regular blood Organization (WHO) figures estimate that 5% of world population is carrier for haemoglobin disorders.
4 With exception of a few deletions, vast majority of b thalassaemias are caused by point mutations within the gene or its immediate flanking sequences.
Thalassaemia intermedia (TI) includes patients of thalassaemia with clinical severity intermediate between asymptomatic thalassaemia minor and transfusion dependent thalassaemia major (TM).
Characterization of a new alpha zero thalassaemia defect in the South African population.
2% siblings identified as beta thalassaemia carriers in the study as opposed to 5-8% carriers in the general population.