Thalassemia

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Related to Thalassemia intermedia: Thalassemia minor

thalassemia

[‚thal·ə′sē·mē·ə]
(medicine)
A hereditary form of hemolytic anemia resulting from a defective synthesis of hemoglobin: thalassemia major is the homozygous state accompanied by clinical illness, and thalassemia minor is the heterozygous state and may not have evident clinical manifestations. Also known as Mediterranean anemia.

Thalassemia

 

(also thalassanemia), a familial hemolytic anemia, first detected in 1925 among inhabitants of the Mediterranean region. Thalassemia is caused by disturbances in hemoglobin synthesis.

References in periodicals archive ?
On the other hand, the primary reason we consider our patient as thalassemia intermedia is that he is compound heterozygous for 3'UTR+1570 T>C and Cod 8(-AA) beta-globin gene mutations.
Ozsoylu S: Thalassemia trait as thalassemia intermedia.
They were presented with similar clinical and hematological phenotype consistent with a diagnosis of thalassemia intermedia.
HemaQuest President and CEO John Longenecker, PhD, said, "These clinical trials provide evidence of the safety and potential therapeutic activity of HQK-1001 in patients with sickle cell disease and beta thalassemia intermedia.
Venous blood samples from 610 patients with beta thalassemia major, beta thalassemia intermedia and beta thalassemia minor were collected in EDTA.
Hb D/[beta]-thalassemia patients have a disease that has clinical manifestations ranging from mild to moderate disease, resembling either thalassemia minor or thalassemia intermedia [4].
The initial clinical trial is a pharmacokinetic, safety and efficacy study of continuous and intermittent infusions of VX-105 in patients with beta thalassemia intermedia.