Thalassemia

(redirected from Thalassemias)
Also found in: Dictionary, Thesaurus, Medical.

thalassemia

[‚thal·ə′sē·mē·ə]
(medicine)
A hereditary form of hemolytic anemia resulting from a defective synthesis of hemoglobin: thalassemia major is the homozygous state accompanied by clinical illness, and thalassemia minor is the heterozygous state and may not have evident clinical manifestations. Also known as Mediterranean anemia.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Thalassemia

 

(also thalassanemia), a familial hemolytic anemia, first detected in 1925 among inhabitants of the Mediterranean region. Thalassemia is caused by disturbances in hemoglobin synthesis.

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
The population of this study comprised of 1500 patients of beta thalassemia major registered at Fatimid Foundation, Peshawar.
A previous study done by Aleem A, et al 8 showed that majority of hypocalcemics in thalassemia were asymptomatic and only 2/8 (25%) showed paresthesias of hands.
When laboratory features are discordant for a diagnosis of beta thalassemia trait, it is useful to consider other conditions that affect the Hb [A.sub.2] level and red blood cell indices.
Alpha thalassemia is a common single-gene disorder throughout parts of the world where malaria is endemic.
Coexistent iron deficiency was seen in 51% of beta thalassemia patients.
[3,4] In fact, the MCV alone can identify a high number of thalassemia carriers in both adults and children.
Conclusion: Carrying out mass screening programmes throughout Pakistan for the detection of thalassemia carriers and providing them the benefit of marriage counselling may decrease the incidence of thalassemia Major.
He said that for the thalassemia patients the permanent treatment is bone marrow transplantation but unfortunately this surgery is so expansive and at least Rs 2 million is required for this operation.
"The Thalassemia Syndromes", Blood 51:369 (March,1978).
But this treatment leads to progressive deposition of iron in tissues, posing significant risk of severe cardiac, endocrinological, and hepatic complications, which are fatal if not prevented.1 Today many of the complications of Thalassemia seen in developed countries are the result of iron overload.
Although the types of mutations that cause hemoglobin-opathies and thalassemias are very different, the genes that bear the mutation are the same, namely the globin genes and the associated regulatory genes.