The ovary remains the primary source of hyperandrogenism in women with PCOS which is mainly attributed to thecal cell
hyperplasia leading to intense ovarian steroidogenesis.
Franks, "Evidence for a primary abnormality of thecal cell
steroidogenesis in the polycystic ovary syndrome," Clinical Endocrinology, vol.
Effects of thyroid hormones on bovine granulosa and thecal cell
function in vitro: dependence on insulin and gonadotropins.
Cx43 was not detected at the thecal cell
layer or at the border between GCs and oocytes where Cx26 and Cx32 were found to be predominant, respectively (data not shown).
MMP-2 and MMP-9 activities increase during the later period of follicular development and these increments are along with follicular remodeling of granulosa and thecal cells
damage to convoluted seminiferous tubules epithelium, reduction of spermatozoa formation and increase in prevalence of teratospermia, atrtic follicles congestion in stromal tissue, decrease in follicle and oocyte number, increased level of Cr(VI) in blood, increased duration of estrus cycle, disintegrated cell membranes of two layered follicular cells and altered villiform mitochondria in thecal cells
(Li et al., 1999; Murthy et al., 1996; Elbetieha and Al-Hamood, 1997).
LH supports thecal cells
in the ovary, which provide androgens and hormonal precursors for estradiol production.
RC: renal corpuscle; RP: red pulp; WP: white pulp; L: Leydig cells; ST: seminiferous tubule; OC: oocyte; G: granulosa cells; T: thecal cells
. All the images are reduced by 70% compared to the original ones.
FF contains several blood plasma protein components derived from constituents that cross the blood-follicular barrier and several granulosa/theca proteins derived from granulosa and thecal cells
(Nandedkar et al., 1992; Fortune, 1994).
After ovulation Corpus luteum develops from residual follicular granulosa and thecal cells
. At the end of menstrual cycle or during pregnancy, it regresses spontaneously.
Effects of insulin-like growth factor I and insulin on proliferation and on basal and luteinizing hormoneinduced steroidogenesis of bovine thecal cells
: involvement of glucose and receptors for insulin-like growth factor I and luteinizing hormone.
Just before ovulation in Graafian follicles, some thecal cells
differentiate into hypertrophic cells and the follicular basement membrane fragments.