The ovary remains the primary source of hyperandrogenism in women with PCOS which is mainly attributed to thecal cell
hyperplasia leading to intense ovarian steroidogenesis.
Ebola Virus GP and VP40 Localization in Infected Cell Types of Nonhuman Primates and Guinea Pigs(*) VP40 GP Cell Type ISH IHC ISH IHC Macrophages and monocytes + + + - Fibroblasts + + + + FRC + + + + Epithelia([dagger]) + + + + Ovarian thecal cells
+ + + + Hepatocytes([double dagger]) + + + + Adrenal cortical cells([double dagger]) + + + + Renal PCTs - + - - Vero E6 cells([sections]) ND + ND - 293 cells([sections]) ND + ND - (*) ISH indicates in situ hybridization; IHC, immunohistochemistry; FRC, fibroblastic reticular cells; PCT, proximal convoluted tubule; ND,in situ hybridization not done on these samples; +, cell type was consistently labeled by the stated method; -, cell type was consistently unlabeled.
The TGF-[beta] superfamily factors, in particular GDF9 and BMP15, play a critical role in ovarian architecture and fertility, being essential for the proper follicular growth and development, as well as for the formation, growth and function of granulosa and thecal cells
. Such factors have as their main target the granulosa cells, and from their ability of functional modulation of these somatic cells, play a critical role in oocyte maturation and training process.
Loosely organized layers of spindle-shaped cells develop around the layer of granulosa cells and become known as thecal cells
. Unlike the granulosa cell layer, the layer of thecal cells
becomes richly supplied with capillaries.
They may contain granulosa cells, thecal cells
, Sertoli cells, or fibroblasts of gonadal stromal origin.
Notably, NGF activation of TrkA in cultured thecal cells
is reported to be involved in the disruption of gap junctions (Mayerhofer, 1996).
Female fertility depends on the supply and maturation of the ovarian germ cells, i.e., the oocytes and the differentiation and proliferation of ovarian somatic cells, or granulosa and thecal cells
In addition to changing the morphology of the granulosa and thecal cells
, the LH surge induces a remarkable reorganization of follicular tissue.