lipoic acid

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lipoic acid:

see coenzymecoenzyme
, any one of a group of relatively small organic molecules required for the catalytic function of certain enzymes. A coenzyme may either be attached by covalent bonds to a particular enzyme or exist freely in solution, but in either case it participates intimately in
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The Columbia Electronic Encyclopedia™ Copyright © 2013, Columbia University Press. Licensed from Columbia University Press. All rights reserved.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Lipoic Acid


6,8-epi-dithio-octanoic acid, a widespread naturally occurring coenzyme, related to enzymes of the class of oxidoreductases. It exists in the form of crystals with melting point 59°-60°C and was first isolated from bull’s liver in 1941 (30 mg of lipoic acid was obtained from 10 tons of liver).

Lipoic acid participates in the transfer of acyl groups (acid radicals) and in biological oxidation reactions (for example, oxidative decarboxylation of pyruvic and ketoglutaric acids for conversion into acetyl-CoA and succinyl-CoA, respectively, with liberation of carbon dioxide). The oxidized form of lipoic acid is transformed into a reduced form, which is then reconverted into the oxidized form upon action of a specific enzyme:

Lipoic acid is the growth factor (vitamin) in certain microorganisms; it exists in composite protein form in the cells of plant and animal tissues.

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.

lipoic acid

[lī′pō·ik ′as·əd]
C8H14O2S2 A compound which participates in the enzymatic oxidative decarboxylation of α-keto acids in a stage between thiamine pyrophosphate and coenzyme A.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
Finn et al., "Effects of 3-week oral treatment with the antioxidant thioctic acid ([alpha]- lipoic acid) in symptomatic diabetic polyneuropathy," Diabetic Medicine, vol.
It is billed as a new anti-wrinkle moisture lotion and one of the first in the natural channel to feature SPF 30 for daily use, A multi-an-tioxidant complex features Ester-C, vitamin C and thioctic acid to help minimize the effects of sun, stress and time, while replenishing critical moisture levels.
Alpha Lipoic Acid (Thioctic Acid): Alpha lipoic acid modulates glucose and insulin sensitivities, as well as preventing much of the free radical damage secondary to prolonged hyperglycemia.
Haugaard, "Stimulation of glucose utilization by thioctic acid in rat diaphragm incubated in vitro," Biochimica et Biophysica Acta--General Subjects, vol.
It is powered by a Multi-Antioxidant Complex featuring Ester-C--a stable, naturally derived form of vitamin C with powerful antioxidant protection to reduce oxidative stress and help minimize free radical damage to skin cells--and thioctic acid.
Also known as thioctic acid, alpha lipoic acid is a natural and versatile antioxidant with numerous therapeutic uses.
A randomized double-blind placebo-controlled trial of thioctic acid in migraine prophylaxis.
Alpha-lipoic Acid (thioctic acid): A potent antioxidant, it's water and fat soluble and can work both in reductive and oxidative mode.
The effects of the antioxidant alpha-lipoic acid (thioctic acid) were studied in two multicenter, randomized, double-blind placebo-controlled trials.