Thiopental Sodium


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thiopental sodium

[¦thī·ō′pen‚tal ′sōd·ē·əm]
(organic chemistry)
C11H17O2N2NaS Yellow, water-soluble crystals with a characteristic aroma; used in medicine as a short-acting anesthetic. Also known as thiopentone sodium.

Thiopental Sodium

 

(or Pentothal sodium), a medicinal preparation of the anesthetic group. It is mainly used for intravenous anesthesia and is prepared immediately before use. The antagonist of thiopental sodium is bemegride.

References in periodicals archive ?
(ii) The second batch will simultaneously receive thiopental sodium 40 mg/kg + bromazepam 30 mg/kg: this is the reference lot; the third batch will receive the product mixture 5a-d 100 mg/kg + 40 mg/kg of thiopental sodium: this is the batch of the product tested.
See ABBOTT LABORATORIES, PENTOTHAL FOR INJECTION, USP (THIOPENTAL SODIUM) 3-4 (1993), available at http://www.rxlist.com/cgi/generic/thiopental.htm.
After 15 minutes, anaesthesia was induced with 2.5% Thiopental sodium (Thiosol Sodiumf) inj intravenously @ 12.5 mg/ kg b.
Intravenously administered valproate, diazepam and thiopental sodium are more successful, however at the cost of adverse effects.
It is not possible to administer so much of it that a lethal effect is guaranteed, but the substance is quite suitable for producing coma, after which termination may be effected using a muscle relaxant." (47) In the same article, the thiopental dose to be used was stated as, "intravenous administration of 1 g thiopental sodium, if necessary, 1.5-2 g of the product in case of strong tolerance to barbiturates." (48) Apparently the largest dose of thiopental used in the Netherlands was only 2 g (or 2000 mg) and it is therefore not surprising that such a dose was found to be less than 100% lethal.
Induction of anaesthesia was done with Thiopental sodium intravenously till effect and intubated with cuffed endotracheal tube.
Under general anesthesia "using Thiopental sodium in the dose of 50 mg/kg body weight" the trunk of radial nerve was sectioned in axilla on right side.
All dogs received an intramuscular injection of 0.02 mg/kg Atropine sulphate (a) before anaesthesia with intravenous Thiopental sodium (b) (@10 mg/ kg) 'to effect'.
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