Myotonia

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Related to Thomsen's disease: Becker disease, Congenital myotonia

myotonia

[‚mī·ə′tō·nē·ə]
(medicine)
Tonic muscular spasm occurring after injury or infection.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Myotonia

 

a hereditary neuromuscular disease in which a contracted muscle is unable to relax for a long time; muscular relaxation proceeds very slowly. Depending on the clinical course of the disease, congenital, atrophic, cold, and paradoxical forms of myotonia are distinguished. The disease may occur in several members of a family; males are more often affected. There are no marked morphological changes in the nervous system or the muscles. There may be dysfunctions of the autonomic nervous system and the endocrine glands. Increased sensitivity to acetylcholine and potassium are characteristic of the disease. The principal sign of myotonia is impaired myofibril contractility, that is, relaxation of contracted muscles is greatly impaired. The muscles are firm to the touch. Myotonia progresses slowly, with general deterioration frequently setting in after overexposure to low temperatures, mental stress, and excessive fatigue. Treatment includes hormone therapy, vitamin therapy, and physical therapy.

REFERENCE

Badalian, L. O., V. A. Tabolin, and Iu. V. Vel’tishchev. Nasledstvennye bolezni u detei. Moscow, 1971.
The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.