Thrombocytopenia


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thrombocytopenia

[¦thräm·bō‚sīd·ō′pē·nē·ə]
(medicine)
The condition of having an abnormally small number of platelets in the circulating blood.

Thrombocytopenia

 

a decrease in the number of platelets to fewer than 200,000 per mm3 in the peripheral blood. It may result from the redistribution of platelets in the bloodstream or from hemorrhage. Other causes are the intensified loss of platelets associated with thrombocytopenic purpura, splenomegaly, disseminated intravascular thrombosis, and the use of certain drugs. Thrombocytopenia may also result from disturbance of platelet formation in the bone marrow in leukemia or aplastic anemia, and from ionizing radiation. Blood clotting is impaired in thrombocytopenia, resulting in a tendency of the mucous membranes to bleed, as well as in hemorrhaging and the appearance of petechiae in the internal organs. Bleeding usually becomes continuous when the platelet count falls below 20,000–30,000 per mm3 of blood. Therapy involves treatment of the underlying disease, administration of hemostatics, and transfusion of platelets.

References in periodicals archive ?
Majority of the cases (96%) had thrombocytopenia of which 67.16% of patients had grade 1 thrombocytopenia
rRT-PCR showed 2 positive results, from the stored serum of 2 patients with thrombocytopenia who had been seen at Hue University Hospital during 2017 and who had no history of travel to SFTSV-endemic countries, such as China, South Korea, and Japan.
There is inconsistency regarding the clinical significance of thrombocytopenia in ICU setting.
ITP is a rare, serious autoimmune disease characterised by low platelet counts in the blood (a condition known as thrombocytopenia) and impaired platelet production.
There have been promising publications regarding their use in post-APSCT thrombocytopenia recently (5-7).
[USA], Aug 15 ( ANI ): Researchers have now uncovered a new approach for treating thrombocytopenia, a condition with a low blood platelet count.
However, the study--published in the New England Journal of Medicine --also found that women with pregnancy-related complications were more likely to have platelet counts less than 150,000/[mm.sup.3], even in the absence of known causes of thrombocytopenia.
To investigate the cause of thrombocytopenia, the patient underwent a bone marrow trephine and aspiration biopsy.
Liver function disorder (hepatitis) and thrombocytopenia were detected in a 9-year-old boy in state hospital where he had gone due to stomachache and he was transferred into our department in order that thrombocytopenia's reason (thrombocyte 70 x [10.sup.9]/L) was searched.
Advances in genetic testing through next-generation sequencing (NGS) allow for identification of underlying genetic defects and for distinguishing inherited platelet disorder cases from acquired platelet disorders, including immune thrombocytopenia. Accurate diagnosis is essential in guiding medical management of bleeding and associated non-hematologic conditions, assisting with the identification of affected family members, and predicting genetic recurrence risk assessment.
There was severe isolated thrombocytopenia (4000), but no evidence of skin or mucous membranes bleeding.
Thrombocytopenia is not considered a proven side effect of gabapentin, as only one previous report has suggested a relationship [5].