Thrombocytopenic Purpura


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Related to Thrombocytopenic Purpura: thrombotic thrombocytopenic purpura

thrombocytopenic purpura

[¦thräm·bō¦sīd·ō¦pē·nik ′pər·pə·rə]
(medicine)
Hemorrhages in the skin, mucous membranes, and elsewhere associated with a decreased number of thrombocytes per unit volume of blood.

Purpura, Thrombocytopenic

 

(purpura hemorrhagica), a widespread disease of man and animals; one of the group of hemorrhagic diatheses. It is caused by a decrease in the blood platelet count and by disturbances in blood clotting.

Thrombocytopenic purpura may occur as an independent disease (idiopathic thrombocytopenic purpura, or Werlhof’s disease), which is encountered mainly in women and is often chronic. Important in the genesis of thrombocytopenic purpura are the transformation of autoantibodies into platelets, intensified decomposition of platelets in the spleen, and changes in the vascular wall caused by the disappearance of the marginal layer of platelets, which results in hemophilia. Drug-induced thrombocytopenic purpura, which may result from the ingestion of such substances as analgesics, sulfanilamides, or quinine, is characterized by an instantaneous intravascular decomposition of platelets resulting from the formation of antibodies to counter the drug-thrombocyte complex. Symptomatic thrombocytopenic purpura may occur in typhoid, protracted septic endocarditis, splenomegaly, collagen diseases, aplastic anemia, leukemia, and carcinomatous metastases in bone marrow.

The principal clinical symptoms of thrombocytopenic purpura are hemorrhages in the skin and a tendency toward bleeding in the mucous membranes. The type of thrombocytopenia is determined through a biopsy of the bone marrow. Treatment is effected by administering corticosteroids and hemostatics or by removing the spleen.

REFERENCE

Kassirskii, I. A., and G. A. Alekseev. Klinicheskaia gematologiia, 4th ed. Moscow, 1970.

A. N. SMIRNOV

References in periodicals archive ?
Idiopathic thrombocytopenic purpura complicating pregnancy.
Subdural hematoma associated with immune thrombocytopenic purpura in two different clinical settings.
Current management and therapeutical perspectives in thrombotic thrombocytopenic purpura. Presse Med 2012;41:163-76.
An update on the management of immune thrombocytopenic purpura and emerging treatment options: A review and case report.
Thrombotic thrombocytopenic purpura and other thrombotic microangiopathic hemolytic anemias: diagnosis and classification.
Microangiopathic haemolytic anaemia resembling thrombotic thrombocytopenic purpura in systemic lupus erythematosus: the role of ADAMTS13.
Janowitz, "Celiac sprue, idiopathic thrombocytopenic purpura, and hepatic granulomatous disease: an autoimmune linkage?," Journal of Clinical Gastroenterology, vol.
A diagnosis of thrombotic thrombocytopenic purpura was made despite a negative test for anti-ADAMTS13 antibodies [4].
Blanchette, "Medical progress: immune thrombocytopenic purpura," The New England Journal of Medicine, vol.
Tsai, "Pathophysiology of thrombotic thrombocytopenic purpura," International Journal of Hematology, vol.
Thrombotic thrombocytopenic purpura (TTP) is a rare hematological disorder that approved fatal in most cases if not treated properly.
Segal, "The epidemiology of immune thrombocytopenic purpura," Current Opinion in Hematology, vol.