Thrombocytopenia is a common complication of chronic liver disease (CLD) and may be caused by multiple mechanisms including splenic sequestration and decreased production of thrombopoietin
Use of eltrombopag, a thrombopoietin
receptor agonist, in post-transplantation thrombocytopenia.
Romiplostim is another thrombopoietin
receptor agonist which is administered intravenously.
ANGPT1: angiopoietin 1; ANGPT2: angiopoietin 2; JAG1: jagged 1; OPN: osteopontin; RUNX2: runt-related transcription factor 2; SDF1: stromal cell- derived factor 1; TPO: thrombopoietin
; VCAM1: vascular cell adhesion molecule 1.
Savas, "Serum thrombopoietin
levels in patients with chronic hepatitis and liver cirrhosis, and its relationship with circulating thrombocyte counts," Hepato-Gastroenterology, vol.
Omiyama et al., "Circulating thrombopoietin
level in chronic immune thrombocytopenic purpura," British Journal of Haematology, vol.
(TPO) is the key cytokine that promotes the production of megakaryocytes and platelets, and it is primarily synthesized in the liver .
The cells were cultured in 200 mL IMDM supplemented with 10% fetal calf serum, 1% bovine serum albumin, 2 mM L-glutamine, 50 mM 2-b-mercaptoethanol, 10 ng/mL stem cell factor, 10 ng/mL thrombopoietin
, and 10 ng/mL IL-3, as described previously (14).
AMG531 is a thrombopoietin
receptor agonist being evaluated in the form of an injection formulation.
One such novel agent is thrombopoietin
receptor agonists like eltrombopag, romiplostim with promising results and lesser potential for immunogenicity.
The effect of high altitude on platelet counts, thrombopoietin
and erythropoietin levels in young Bolivian airmen visiting the Andes.
The decreased thrombopoietin
production is the reason.