TPO

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TPO

TPO

(Twisted Pair Only) The use of twisted pair wire when other options are available. For example, a TPO suffix at the end of an earlier 3com Ethernet adapter model numbers indicated the card had only an RJ45 connector. TP meant RJ45 and AUI connectors, TPC was RJ45 and BNC, and COMBO cards provided all three. See 10Base2 and 10Base5.
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Localization and regulation of thrombopoietin mRNa expression in human kidney, liver, bone marrow, and spleen using in situ hybridization.
Avatrombopag is an investigational oral thrombopoietin receptor agonist.
Thrombopoietin, a hormone that regulates production of platelets, has been found to peak shortly after birth and gradually decline to adult concentrations (26), which could explain the higher platelet counts observed in early childhood.
An example is the protein tyrosine kinase JAK2, which transduces signals from ligand-bound cell surface receptors for thrombopoietin (TPOR/MPL) and erythropoietin (EPOR).
There are several second-line therapies: spelenectomy, rituximab, danazol, azathioprine, and thrombopoietin agonists such as eltrombopag and romiplostim.
Plasma thrombopoietin level and platelet indices in hemodialysis patients receiving recombinant human erythropoietin.
However other drugs may be used in future if the thrombopoietin (TPO) mimetic proves safe and effective in various paediatrics trials currently in progress.
Thrombopoietin concentrations are low in patients with cirrhosis and thrombocytopenia and are restored after orthotopic liver transplantation.
7 The cause is multifactorial due in part to increased sequestration in the spleen bone marrow suppression by HCV infection and by interferon treatment and reduced production of thrombopoietin (a cytokine that regulates megakaryocyte maturation and platelet production).
Bone marrow megakaryocytes may be normal or increased during infection, but platelet destruction is increased, with significantly elevated thrombopoietin levels in patients with severe infection (3-5).