thromboxane

(redirected from Thromboxanes)
Also found in: Dictionary, Medical.
Related to Thromboxanes: Eicosanoids, Leukotrienes

thromboxane

[‚thräm′bäk‚sān]
(biochemistry)
Any member of a group of 20-carbon fatty acids related to the prostaglandins and derived mainly from arachidonic acid.
References in periodicals archive ?
Prostacyclin opposes the effects of thromboxane, a thrombogenic and atherogenic eicosanoid.
Reduced levels of circulating thromboxane prevent platelet aggregation and vasoconstriction such that bleeding time is prolonged when patients are taking NSAIDs.
Licofelone also inhibits both cyclooxygenase (COX)-1 and COX-2, the enzymes that convert arachidonic acid into prostaglandins and thromboxanes, which means that the drug is a dual LOX-COX inhibitor.
Thromboxane mediates diapedesis after ischemia by activation of neutrophil adhesion receptors interacting with basally expressed intercellular adhesion molecule-1.
The fractions containing prostaglandins and thromboxanes were resolved on TLC.
Some researchers are testing drugs that specifically inhibit the synthesis of thromboxanes, substances made by the body that cause vessels to constrict.
Secondly, they are required as precursors to the eicosanoids, which includes various end products such as prostaglandins, leukotrie-nes, and thromboxanes, all of which profoundly influence cellular reactions.
Damaged or distressed (ischemic) endothelium leads to the formation of prothrombogenic substances such as factor XII, thromboxanes, endothelin, TF, and various growth factors.
Richard Hunt, Professor of Medicine and Gastroenterology at McMaster University Medical Centre in Hamilton, Canada commented: "The commonly accepted mechanism of action of traditional non-specific NSAIDs is the inhibition if COX, which results in a reduced synthesis of prostaglandins and thromboxanes and is the basis for the anti-inflammatory effect of these drugs.
Agency : Ulsan Metropolitan City Office of Education thromboxanes Jiangbei Elementary School
Contract awarded for East Hall (2 thromboxanes dongoe 6 buildings) LED lamp replacement, Ltd