thromboxane

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Related to Thromboxanes: Eicosanoids, Leukotrienes

thromboxane

[‚thräm′bäk‚sān]
(biochemistry)
Any member of a group of 20-carbon fatty acids related to the prostaglandins and derived mainly from arachidonic acid.
References in periodicals archive ?
Aspirin irreversibly inhibits cyclooxygenase (COX)-1 by acetylation of serine-530, which is close to the active site, and thereby affects platelet-dependent thromboxane [A.
2] test measures a metabolite of serum thromboxane [B.
In an interesting study, Zimmermann et al found that patients who responded to aspirin before coronary artery bypass surgery became transiently resistant to aspirin for up to 10 days after surgery, but terbogrel, a combined inhibitor of thromboxane synthetase and thromboxane receptor, equally prevented thromboxane formation by platelets before and after surgery (18).
2] levels, which serve as a marker of thromboxane generation, in a subgroup of patients taking aspirin (21).
Several other important studies are in progress, one of which is the Research Evaluation to Study Individuals Who Show Thromboxane or P2Y12 Receptor Resistance (RESISTOR) trial, which will examine variability in response to antiplatelet therapies.
In addition, in acute inflammatory states, such as acute coronary syndrome and PCI, the macrophage's increased TxA2 production may play an important role in overriding the effect that aspirin may have on platelet activity, and addition of a thromboxane receptor antagonist may be of benefit during these events.
Differential suppression of thromboxane biosynthesis by indobufen and aspirin in patients with unstable angina.
On the other hand, thromboxane BZ is generated during the activation of platelets by the enzymatic action of cyclooxygenase on arachidonic acid.
Thus, platelet factor 4, [beta]-thromboglobulin, serotonin, and thromboxane [B.
Prostacyclin opposes the effects of thromboxane, a thrombogenic and atherogenic eicosanoid.
Cardiovascular responses to the isoprostanes iPF(2 [alpha])-III and iPE(2)-III are mediated via the thromboxane A(2) receptor in vivo.
Local amplification of platelet function by 8-epi prostaglandin F-2 [alpha] is not mediated by thromboxane receptor isoforms.