Thyroglobulin


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thyroglobulin

[¦thī·rō′gläb·yə·lən]
(biochemistry)
An iodinated protein found as the storage form of the iodinated hormones in the thyroid follicular lumen and epithelial cells.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Thyroglobulin

 

a glycoprotein produced by the follicles of the thyroid gland; a direct precursor of the thyroid hormones. The carbohydrate and protein constituents of thyroglobulin are synthesized in the ribosomes of the thyroid epithelium. Subsequent iodination of the residues of the amino acid tyrosine, which are part of the thyroglobulin molecule, results in the formation of thyroxine and triiodothyronine. These are released into the blood after splitting off from thyroglobulin under the influence of the proteolytic enzymes of the thyroid gland. The cells’ ability to iodinate thyroglobulin arises after the appearance of the endoplasmic reticulum in the gland, the formation of follicles, and the secretion of thyrotropin by the hypophysis.

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
Immunohistochemical stain on core biopsy showing negative staining for Thyroglobulin (Thyroglobulin stain X 200).
Clinical and biochemical features Values Age, yrs 16.5 (7-18) Tumor size, mm 24 (13-46) pN0/N1a/N1b 2/1/11 Extrathyroid extension: no/minimal/massive 5/8/1 Thyroid ablation 2 cases ([greater than or equal to] 30 mCi) Whole body scintigraphy 3 cases ([less than or equal to]13 mCi) Follow-up period, yrs 8.4 (3.5-15.8) Lymph node recurrence 5 cases Number of Tg measurements 6.5 (4-12) Tg-DT, yrs 8.3 (-4.5-147) 1/Tg-DT 0.12 (-0.29-0.51) hTV-DT, yrs 0.5 (0.3-0.6) 1/hTV-DT 1.99 (1.68-4.01) Values are median (ranges) and numbers of cases, Tg: thyroglobulin, Tg-DT: thyroglobulin-doubling time, and hTV-DT: hypothetical tumor volume-doubling time.
Ringseis, "Sterol regulatory element-binding proteins are transcriptional regulators of the thyroglobulin gene in thyroid cells," Biochimica et Biophysica Acta, vol.
Serum thyroglobulin levels after fine-needle aspiration of thyroid nodules.
In Figure 3, a strong labeling of thyroglobulin in an interfollicular space is evident in old animals.
The rise of the thyroglobulin antibodies and anticardiolipin antibody indicated abnormal autoimmunity.
Rapoport, "Why measure thyroglobulin autoantibodies rather than thyroid peroxidase autoantibodies?" Thyroid, vol.
Kammori et al., "Thyroglobulin suppresses thyroid-specific gene expression in cultures of normal but not neoplastic human thyroid follicular cells," Journal of Clinical Endocrinology and Metabolism, vol.
The IHC characterization of the thyroid cells was performed with antibodies against thyroglobulin (specific for thyroid follicular cells) and calcitonin (specific for thyroid C-cells [or parafollicular cells]) (RAMOS-VARA et al., 2002; CIAPUTA et al., 2014).
Background: Postoperative preablative stimulated thyroglobulin (ps-Tg) has been evaluated in predicting prognosis and success of ablation regarding differentiated thyroid cancer (DTC); however, its relationship with recurrence risk and radioiodine decision-making remains uncertain, especially in Chinese DTC patients.
Studies have shown that microvilli of thyroid follicular cells phagocytose colloid from follicular lumina so that thyroid hormones formed on the scaffold of thyroglobulin can be processed intracellularly and released into circulation (French & Hodges, 1977).