Thyroglobulin


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thyroglobulin

[¦thī·rō′gläb·yə·lən]
(biochemistry)
An iodinated protein found as the storage form of the iodinated hormones in the thyroid follicular lumen and epithelial cells.

Thyroglobulin

 

a glycoprotein produced by the follicles of the thyroid gland; a direct precursor of the thyroid hormones. The carbohydrate and protein constituents of thyroglobulin are synthesized in the ribosomes of the thyroid epithelium. Subsequent iodination of the residues of the amino acid tyrosine, which are part of the thyroglobulin molecule, results in the formation of thyroxine and triiodothyronine. These are released into the blood after splitting off from thyroglobulin under the influence of the proteolytic enzymes of the thyroid gland. The cells’ ability to iodinate thyroglobulin arises after the appearance of the endoplasmic reticulum in the gland, the formation of follicles, and the secretion of thyrotropin by the hypophysis.

References in periodicals archive ?
Serum thyroglobulin measurement in the follow-up of patients treated for differentiated thyroid cancer.
Thyroidectomy, postoperative iodine ablation, thyroxine replacement and careful follow up with serum thyroglobulin levels are associated with fewer cancer recurrences and tumour related deaths (9).
The utility of serum thyroglobulin measurement at the time of remnant ablation for predicting disease-free status in patients with differentiated thyroid cancer: A meta-analysis involving 3947 patients.
Generally, total body scan negative with low stimulated thyroglobulin is an excellent prognostic sign.
Predictive value for disease progression of serum thyroglobulin levels measured in the postoperative period and after (131)I ablation therapy in patients with differentiated thyroid cancer.
36) Another study compared 124I PET-CT with FDG PET-CT in patients with elevated thyroglobulin but negative ultrasonography and found the sensitivities for WDTC detection to be 80% and 70%, respectively.
Negative staining for keratin, thyroglobulin and positive staining for endothelial cell markers (CD31, CD34, Faktor VIII, Ulex europaeus) in immunohistochemical examinations differentiates it from anaplastic (undifferentiated) carcinoma of the thyroid (2).
Induction of autoimmunity in good and poor responder mice with mouse thyroglobulin and lipopolysaccharide.
The needle wash specimen revealed an intact PTH level of 29,994 pg/ml (Control <30 pg/ml) and a thyroglobulin level of less than 0.
In the patients who underwent bilateral total thyroidectomy, serum thyroglobulin was less than one nanogram per milliliter in 42 patients (93.
It is known as a multiligand molecule and such proteins as lipoprotein lipase (LPL), Neurotensin 3 (NT3), Receptor associated protein (RAP), proNGF, and thyroglobulin are among its potential ligands (2, 3-5).
4]) >70 pmol/L (normal, 10-20 pmol/L); negative antithyroid peroxidase and antithyroglobulin antibodies; normal complete blood count, calcium, and alkaline phosphatase; and low levels of thyroglobulin.