Predictive Value of Preablation Stimulated Thyroglobulin
and Thyroglobulin/Thyroid-Stimulating Hormone Ratio in Differentiated Thyroid Cancer.
Immunohistochemical stain on core biopsy showing negative staining for Thyroglobulin
stain X 200).
Clinical and biochemical features Values Age, yrs 16.5 (7-18) Tumor size, mm 24 (13-46) pN0/N1a/N1b 2/1/11 Extrathyroid extension: no/minimal/massive 5/8/1 Thyroid ablation 2 cases ([greater than or equal to] 30 mCi) Whole body scintigraphy 3 cases ([less than or equal to]13 mCi) Follow-up period, yrs 8.4 (3.5-15.8) Lymph node recurrence 5 cases Number of Tg measurements 6.5 (4-12) Tg-DT, yrs 8.3 (-4.5-147) 1/Tg-DT 0.12 (-0.29-0.51) hTV-DT, yrs 0.5 (0.3-0.6) 1/hTV-DT 1.99 (1.68-4.01) Values are median (ranges) and numbers of cases, Tg: thyroglobulin
, Tg-DT: thyroglobulin-doubling time, and hTV-DT: hypothetical tumor volume-doubling time.
Ringseis, "Sterol regulatory element-binding proteins are transcriptional regulators of the thyroglobulin
gene in thyroid cells," Biochimica et Biophysica Acta, vol.
levels after fine-needle aspiration of thyroid nodules.
In Figure 3, a strong labeling of thyroglobulin
in an interfollicular space is evident in old animals.
The rise of the thyroglobulin
antibodies and anticardiolipin antibody indicated abnormal autoimmunity.
Rapoport, "Why measure thyroglobulin
autoantibodies rather than thyroid peroxidase autoantibodies?" Thyroid, vol.
Kammori et al., "Thyroglobulin
suppresses thyroid-specific gene expression in cultures of normal but not neoplastic human thyroid follicular cells," Journal of Clinical Endocrinology and Metabolism, vol.
The IHC characterization of the thyroid cells was performed with antibodies against thyroglobulin
(specific for thyroid follicular cells) and calcitonin (specific for thyroid C-cells [or parafollicular cells]) (RAMOS-VARA et al., 2002; CIAPUTA et al., 2014).
Background: Postoperative preablative stimulated thyroglobulin
(ps-Tg) has been evaluated in predicting prognosis and success of ablation regarding differentiated thyroid cancer (DTC); however, its relationship with recurrence risk and radioiodine decision-making remains uncertain, especially in Chinese DTC patients.
Studies have shown that microvilli of thyroid follicular cells phagocytose colloid from follicular lumina so that thyroid hormones formed on the scaffold of thyroglobulin
can be processed intracellularly and released into circulation (French & Hodges, 1977).