tight junction

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tight junction

[¦tīt ′jəŋk·shən]
(cell and molecular biology)
An intercellular junction composed of a series of fusions of the junctional membrane, forming a continuous seal; serves as a selective barrier to small molecules and as a total barrier to large molecules. Also known as impermeable junction; occluding junction; zonula occludens.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
Nava, "Tight junctions, from tight intercellular seals to sophisticated protein complexes involved in drug delivery, pathogens interaction and cell proliferation," Advanced Drug Delivery Reviews, vol.
Goldblum et al., "Identification of human zonulin, a physiological modulator of tight junctions, as prehaptoglobin-2," Proceedings of the National Academy of Sciences of the United States of America, vol.
Both model systems have similar expression of integral membrane proteins at tight junctions but differ in expression of accessory proteins such as ZO-2.
adhaerens lacks the tight junctions or septate junctions that typically accompany adherens junctions in Eumetazoa (Ganot et al., 2015), close membrane appositions manifesting a vague periodic structure often lie nearby, in the clefts between the lateral surfaces of cells in the epithelium (Ruthmann et al., 1986).
Butyrate promotes the recovering of intestinal wound healing through its positive effect on the tight junctions. J.
Evaluation of gene transcription of intestinal transporters and tight junctions
To try to explain the reasons for possible variations in milk stability between groups of cows, the permeability of mammary gland cell tight junctions was analyzed through lactose content in plasma from heparinized vacutainers, which was determined with the use of an enzymatic assay kit [(Lactose Assay Kit - Bio Vision Research Products, Mountainview, CA, USA) in a microplate reader (Bio-Tek Instruments, model EL808 Micro-plate Reader (Winooski, USA)].
it has also been shown that [Na.sup.+]/[K.sup.+]/ATPase has a fundamental role in regulating mouse trophectoderm tight junction formation and function (22).
To eliminate cell-to-cell communication and the tight junctions, the Monell scientists used a rodent model and applied sophisticated neurophysiological techniques to isolate single living taste cells.
"We have shown that distinct components of these blood vessels termed tight junctions are altered in Alzheimer's disease.
Dr James Keaney, who spearheaded the Trinity study, said: "We have shown that distinct components of these blood vessels termed tight junctions are altered in Alzheimer's disease."