tight junction

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tight junction

[¦tīt ′jəŋk·shən]
(cell and molecular biology)
An intercellular junction composed of a series of fusions of the junctional membrane, forming a continuous seal; serves as a selective barrier to small molecules and as a total barrier to large molecules. Also known as impermeable junction; occluding junction; zonula occludens.
References in periodicals archive ?
Carbon monoxide-releasing molecule-2 reduces intestinal epithelial tight-junction damage and mortality in septic rats.
Alcohol and its metabolites cause paracellular permeability by acting on the tight-junction complex, which melds two adjoining cells together.
For TEER evaluation, the polyphenol fractions from Red Chicory of Treviso and Variegated Chicory of Castelfranco hydrolysed extracts have been studied on Caco-2 cell monolayers to test the changes in tight-junction (TJ) permeability by TEER, the phenol red passage, and histological analysis.
Occludin and claudins in tight-junction strands: leading or supporting players?
Mullin hypothesized that the tight-junction barrier is damaged in patients with BE, creating a sucrose leak.
Freeze fracture analysis demonstrated that the cells possessed tight-junction sealing strands and gap junctions.
Moreover, the Zot-induced change in intestinal tight-junction permeability reverses itself within a half hour, Fasano adds.
Even in the absence of alcohol, a USF diet resulted in downregulation of intestinal expression of tight-junction protein mRNA compared with an SF diet.