Carbon monoxide-releasing molecule-2 reduces intestinal epithelial tight-junction
damage and mortality in septic rats.
Alcohol and its metabolites cause paracellular permeability by acting on the tight-junction
complex, which melds two adjoining cells together.
For TEER evaluation, the polyphenol fractions from Red Chicory of Treviso and Variegated Chicory of Castelfranco hydrolysed extracts have been studied on Caco-2 cell monolayers to test the changes in tight-junction
(TJ) permeability by TEER, the phenol red passage, and histological analysis.
Occludin and claudins in tight-junction
strands: leading or supporting players?
Mullin hypothesized that the tight-junction
barrier is damaged in patients with BE, creating a sucrose leak.
Freeze fracture analysis demonstrated that the cells possessed tight-junction
sealing strands and gap junctions.
Moreover, the Zot-induced change in intestinal tight-junction
permeability reverses itself within a half hour, Fasano adds.
Even in the absence of alcohol, a USF diet resulted in downregulation of intestinal expression of tight-junction
protein mRNA compared with an SF diet.