tumor necrosis factor

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tumor necrosis factor

[¦tü·mər nə′krō·səs ‚fak·tər]
(immunology)
A monokine that induces leukocytosis, fever, weight loss, the acute-phase reaction, and necrosis of some tumors.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
When they inhibited A20 expression, they gave more TNFa to the aggressive cells, the previously diligent cancer cells started dying off.
The frequency of the LTA +252 (GG) and TNFA -238 (AA) minor homozygote genotypes was higher among the patient group compared to the control ones (14.9% vs.
Influence of TNF[alpha] gene polymorphisms on TNFa production and disease.
The decreased expression of Bcl-2 may cause apoptosis by tumor necrosis factor apoptosis-inducing ligand and increased levels of TNFa expressed [158].
Caption: Figure 7: Quantitative PCR analysis of TNFa expression in the mouse cornea.
Recientemente se han encontrado mas de 420 genes relacionados con esta patologia, incluyendo los genes que codifican para TLR4, FBXO11, TNFa, entre otros.
We further examined the expression of tnfa as an inflammatory cytokine responsible for insulin resistance, as well as sirt1 and sod2 as targets genes of Vash1 in ECs, but we could not find any differences in their expression levels between WT mice and [vash1.sup.-/-] mice in their WAT (Figures 4(a) and 4(b)).
There is a considerable association between serum albumin and CRP levels in CKD children, as CRP levels boost up there is a reduction in serum albumin, the reason for this is that as the pro-inflammatory cytokines such as IL-1, IL-6 and TNFa cause an increase in positive APRs in liver they also cause reduction in synthesis of albumin and other negative APRs.8 CRP and albumin are together acute phase reactants, of which CRP is positive APR (acute phase reactant) while albumin is negative APR.
EYS606 is a combination product and method consisting of a plasmid, encoding for a soluble TNFa receptor, associated to a high precision electro-transfection-injection system (ETIS).
J&J's Simponi (golimumab) is a fully-human IgG1 mAb specific for TNFa. It inhibits TNFa activity, thereby blocking the inflammatory activity of this cytokine and downstream reactions.
Cytokines that were found to affect bone metabolism and thereby orthodontic tooth movement include interleukin 1 (IL-1) interleukin 2 (IL-2) inter- leukin 3 (IL-3) interleukin 6 (IL-6) interleukin 8 (IL-8) tumor necrosis factor alpha (TNFa) gamma interferon (IFN) and osteoclast differentiation factor (ODF).