Inhibitor

(redirected from Topoisomerase I)
Also found in: Dictionary, Thesaurus, Medical.

inhibitor

[in′hib·əd·ər]
(aerospace engineering)
A substance bonded, taped, or dip-dried onto a solid propellant to restrict the burning surface and to give direction to the burning process.
(chemistry)
A substance which is capable of stopping or retarding a chemical reaction; to be technically useful, it must be effective in low concentration.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Inhibitor

 

a circuit having m + n inputs and a single output, at which a signal can appear only when there are no signals on the m inputs (inhibiting). The other n inputs (principal) form one of the two logic connections, “AND” or “OR.” Inhibitors are used extensively in computers. They are very often understood to be a circuit having a single principal input and a single inhibiting input. A signal appears at the output of such a circuit when a signal is present on the principal input but there is none on the inhibiting input. Such an inhibitor is called an anticoincidence gate; its conventional representation is given in Figure 1.

Figure 1. Block diagram of an anticoincidence gate (inhibitor) with m — 1 and n 1:(A) principal input, (Q) inhibiting input, (Ga) anticoincidence gate

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.

inhibitor

A substance added to paint to retard drying, skinning, mildew growth, etc. Also see corrosion inhibitor, inhibiting pigment, drying inhibitor.
McGraw-Hill Dictionary of Architecture and Construction. Copyright © 2003 by McGraw-Hill Companies, Inc.
References in periodicals archive ?
[sup][19] Perturbed DNA topoisomerase I activity can affect fragile-site breakage at the RET oncogene.
A topoisomerase I inhibitor (topotecan) had a tumor-suppressive effect in chemoresistant ovarian cancer-initiating cells.
Liu, "Camp-tothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I," Journal of Biological Chemistry, vol.
Rothenberg, "Topoisomerase I inhibitors: review and update,"
As can be seen from Figure 4, all of the Camptothecins are potent topoisomerase I inhibitors and all of them show this property more 0.781 .
Previous papersdemonstrated that Camptothecins have anticancer activities, scientists mentioned antineoplatic and topoisomerase I inhibitor activity of Camptothecins (12).
As Figure 1, A indicates, the oligonucleotide contains a high-efficiency cleavage site for topoisomerase I.[31] To eliminate the possibility that topoisomerase I was binding to the oligonucleotide to form a complex, 28 units of topoisomerase I from calf thymus were incubated with the [[sup.32]P]-labeled oligonucleotide for 15 minutes at room temperature.
However, based on our results, the following reactions appear to be involved: (1) Hoechst 33342-induced loss of topoisomerase I activity; (2) Hoechst 33342-induced blockade of transcription at the TATA box-binding protein/TATA box element-binding step; (3) Hoechst 33342-induced mitochondrial dysfunction; and (4) intracellular accumulation of E2F-1.
Specificity of anti-Scl70 antibodies in scleroderma: increased sensitivity of detection using purified DNA topoisomerase I from calf thymus.
Evodiamine stabilizes topoisomerase 1-DNA cleavable complex to inhibit topoisomerase I activity.
A series of assays for target-specific pharmacodynamic biomarkers for etirinotecan pegol, including the molecular target topoisomerase I, have been established and are being assessed in the study.
16 November 2011 - Nektar Therapeutics (NASDAQ:NKTR) announced on Tuesday positive results of its preclinical trials of NKTR-102, a topoisomerase I inhibitor, at the 2011 AACR-NCI-EORTC International Conference on Molecular Targets and Cancer that is currently underway in San Francisco.