topoisomerases


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topoisomerases

[¦tä·pō·ī′säm·ə‚rās·əz]
(biochemistry)
Any of a group of enzymes capable of relaxing, unwinding, unpackaging, or changing the degree of supercoiling of deoxyribonucleic acid fiber.
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Keywords: Helichrysum aureonitens; Galangin; Flavonol; Antibacterial activity; 4-quinolone; Topoisomerase; Staphylococcus aureus
This gives a very fast readout of how topoisomerases are able to untwist DNA, and how this process can be disrupted by drugs such as anti-cancer therapeutics and antibiotics.
Level of DNA topoisomerase IIa mRNA predicts the treatment response of relapsed acute leukemic patients.
As in genomic DNA, replication and transcription processes exert topological stresses on mtDNA molecules which are relieved by native topoisomerases [197, 275].
This study was performed to elucidate the role of a topoisomerase I inhibitor (topotecan) in the treatment of chemoresistant ovarian cancer-initiating cells.
Zylka said that a temporary exposure to a topoisomerase inhibitor in utero has the potential to have a long-lasting effect on the brain, by affecting critical periods of brain development.
Camptothecine (CPT), a quinoline alkaloid, is a potent inhibitor of the eukaryotic topoisomerase I (Hsiang et al., 1996; Baikar and Malpathak.
Quinolone resistance in Gram-negative pathogens is usually acquired by chromosomal mutations, primarily in the quinolone resistance-determining regions (QRDRs) of the target genes, gyrA and gyrB, which encode DNA gyrase, and parC and parE, which encode topoisomerase IV.
In addition, an important aspect of the choice of topotecan was its effect on a vital cellular process, namely, the role of topoisomerase I on DNA processes.
Instead, drugs that inhibit the activity of DNA-unwinding proteins called topoisomerases did the trick.