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Related to Transferases: Lyases, Ligases, Hydrolases, Isomerases


Any of various enzymes that catalyze the transfer of a chemical group from one molecule to another.



any of a class of enzymes that catalyze the transfer of a chemical group from one compound (the donor) to another (the acceptor). Transferases are common in plant and animal tissues, as well as in microorganisms. They play a leading role in intermediary metabolism, participating in the transformations of carbohydrates, amino acids, nucleic acids, lipids, and other biologically important compounds.

The transferase class includes more than 450 enzymes, divided by the chemical nature of the group being transferred into subclasses. Examples include the subclasses that catalyze the transfer of single-carbon groups (methyltransferases), glycosyl groups (glycosyltransferases), nitrogen-bearing groups (aminotransferases, or transaminases), and phosphate groups (phosphotransferases). The transferases of the various subclasses have different coenzymes.

The mechanism of the catalytic action of the transferases studied to date includes the formation of an intermediate made up of the enzyme and group being transferred. For example, in the transfer of the acetyl radical (CH3CO—), an acetylated enzyme is formed in the first stage of the reaction, followed by the transfer of the radical to the acceptor and the liberation of the enzyme. The names of transferases are formed according to the sequence dononacceptor-transferred group-transferase. For example, the enzyme that catalyzes the transfer of the phosphate group from adenosinetriphosphate (ATP) to creatine is called ATP:creatine-phosphotransferase. Several transferases have been obtained in crystalline form.


Nomenklatura fermentov. Moscow, 1966. (Translated from English.)
Kretovich, V. L. Vvedenie v enzimologiiu, 2nd ed. Moscow, 1974.


References in periodicals archive ?
Crystallographic and functional characterization of the fluorodifen-inducible glutathione transferase from glycine max reveals an active site topography suited for diphenylether herbicides and a novel L-site.
Glutathione transferase isozymes of diamondback moth larvae and their role in the degradation of some organophosphorus insecticides.
Purification of multiple glutatbione transferases involved in herbicide detoxification from wheat (Triticum aestivum L.
Hence, the present work is carried out to determine the effect of fluoride intoxication on amino transferase enzyme activity in fresh water cat fish, Clarias batrachus.
argentatum were considerably simpler (figure 1), presenting fewer rubber transferase candidates.
Piatigorsky, Structure, Mechanism and Evolution of Class Mu and Sigma Glutathione Transferases, in Glutathione S-Transferases: Structure, Function, and Clinical Implications, N.
Hepatocellular integrity in liver donors and recipients indicated by glutathione transferase a.
Association of glutathione-S- transferase P1 (GSTP1) and group-specific component (GC) polymorphism with the risk of asthma in Pakistani Population.
With this information it appears that alachlor may not be as good a substrate with human GSH transferases as compared to rat GSH transferases.