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Related to Transferrin: Transferrin saturation, TIBC


Any of various beta globulins in blood serum which bind and transport iron to the bone marrow and storage areas.



(also siderophilin), any of a group of related complex proteins (glycoproteins) that transport Fe3+ iron ions in organisms. The carbohydrate component of transferrins constitutes approximately 5.5 percent. The molecular weight is approximately 80,000.

Transferrins occur in blood plasma, milk, and egg albumin (conalbumin). In blood plasma, their main functions are the transport of iron (with one molecule of transferrin binding two atoms of trivalent iron) to the reticulocytes, where hemoglobin is synthesized, and the maintenance of the Fe2+/Fe3+ ratio at a certain level. Upon electrophoresis of plasma proteins, transferrin is found in the β-globulin fraction. Transferrins are found in various genetically dependent forms, which have similar physical and chemical properties. A deficiency of transferrin in organisms leads to a number of pathological states caused by disruption of iron metabolism.


Glikoproteiny, vol. 2. Moscow, 1969. (Translated from English.)
References in periodicals archive ?
Serum ferritin (Cat # BC-1025; BioCheck, United States) (reference range: male: 28-365 ng/dl; female: 5-148 ng/dl) and soluble transferrin receptor (Cat # YHB2785Hu, YH Bioresearch China) (reference range: male: 2.
However, the iron from different states such as absorbed iron in duodenal enterocytes or stored within hepatocytes or recycled by macrophages; ultimately pass from cytoplasm of cells to the transferrin (Ganz et al.
The mean serum transferrin and ferritin in control group was 293 [+ or -] 32.
This study used Western blotting to detect transferrin and ENOSF1 expression.
The conjugates were successfully delivered to cancer cells (in vitro) through transferrin receptors and their binding was characterized by immunofluorescence and immunoperoxidase microscopy.
Transferrin saturation percentage was high in group B as compared to group A (p = 0.
Total iron-binding capacity (TIBC) is performed by drawing blood and measuring the maximum amount of iron that it can carry, which circuitously measures transferrin, since transferrin is the most dynamic carrier.
Transferrin saturation is <20% indicates iron deficiency in all patients.
Complex checks and balances, exemplified by ferritin and transferrin, supply essential iron while blocking noxious iron excess.
Various biochemical parameters are used to diagnose IDA, including ferritin, transferrin saturation (TS), serum iron, and mean corpuscular volume (MCV).
Given the fact that transferrin is a steroidresponsive protein, CDT is known to vary with sex and possibly with age.
Researchers measured levels of transferrin, a protein that transports iron throughout the body and brain, in adolescents and discovered that these transferrin levels were related to detectable differences in both the brain's macrostructure and microstructure when the adolescents reached young adulthood.