Transpeptidation


Also found in: Medical.

Transpeptidation

 

the transfer of an amino acid residue or peptide residue from one compound, usually a peptide, to another in living cells. The reaction, which may be catalyzed by such proteolytic enzymes as trypsin and chymotrypsin, proceeds without substantial changes in free energy, and the total number of peptide bonds (—CO—NH—) in the system remains unchanged. Transpeptidation is used by the cell in the biosynthesis of proteins.

References in periodicals archive ?
Mechanism of heavy metal ion activation of phytochelatin (PC) synthase blocked thiols are sufficient for PC synthase-catalyzed transpeptidation of glutathione and related thiol peptides.
7) Piperacillin, like other [beta]-lactam antibiotics, exerts bactericidal activity by inhibiting the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls, thus inhibiting cell wall biosynthesis of susceptible bacteria.
Different polysaccharide strands are cross-linked by a transpeptidation reaction involving the pentaglycine bridges.