The half-life of CH is 30-60 minutes, but its active metabolite trichloroethanol
duration of action lasts for more than eight hours and up to 35 hours at higher doses.
Chloral hydrate intoxication in a 3-month-old child: Avoidance of hemodialysis by an immediate determination of trichloroethanol
. Clin Biochem 43, 328-330.
Physiological models were added for TCA and trichloroethanol
(TCOH), and a 2-compartment model was added for DCA.
Thus non-polar and therefore not water soluble organic compounds tend to be oxidized within the liver e.g.: trichloroethane oxidised to trichloroethanol
trichloroacetaldehyde and trichloroacetic acid, dichloromethane (methylene chloride CH2Cl2) oxidized to carbon monoxide (CO)
: Organic compound used as a sedative.
A unanimous jury found Miss Humphreys, of Upper Holloway, north London, died of trichloroethanol
poisoning and returned a verdict of death by misadventure.
Chloral hydrate, which is metabolized to trichloroethanol
, produces little habituation and confusion.
Increased formic acid excretion and the development of kidney toxicity in rats following chronic dosing with trichloroethanol
, a major metabolite of trichloroethylene.
Toxicology tests found she died of trichloroethanol
The extent of dichloroacetate formation from trichloroethylene, chloral hydrate, trichloroacetate, and trichloroethanol
in B6C3F1 mice.
2008), which is rapidly metabolized to trichloroacetic acid (TCA) by aldehyde dehydrogenase (ALDH) or to trichloroethanol
(TCE) by alcohol dehydrogenase (ADH).
(2006) concludes that pending the evaluation of a number of additional structural hypotheses, such as enterohepatic recirculation, plasma binding, and flow--or diffusion-limited treatment of tissue distribution, rigorous application of PBPK modeling to risk assessment appears feasible at least for TCE and its major oxidative metabolites, trichloroacetic acid (TCA) and trichloroethanol
. However, there are a number of metabolites of potential toxicologic interest, such as chloral, dichloroacetic acid (DCA), or those derived from glutathione conjugation, for which reliable data are sparse because of analytical difficulties or low concentrations in systemic circulation.