Reverse actin sliding triggers strong myosin binding that moves tropomyosin
The symptoms of systemic anaphylaxis were measured before and after tropomyosin
challenge and scored based on a scoring system : 0, no symptoms; 1, scratch and rub nose and head; 2, swelling eyes and mouth, diarrhea, slow or no activity with an increased respiratory rate after prodding; 3, wheezing and cyanosis around the mouth and the tail; 4, no activity; and 5, death.
Caption: Figure 3: Densitometric profile and SDS-PAGE of a pool of 15 myofibrillar extracts obtained from beef, lamb, and chicken samples extracted with denaturing (a) and nondenaturing (b) solutions (1 = myosin heavy chain; 2 = 180-110 kDa; 3 = [alpha]-actinin; 4 = 95-55 kDa; 5 = desmin; 6 = 51-47 kDa; 7 = actin; 8 = 39 kDa; 9 = troponin T; 10 = tropomyosin
; 11 = 33-23 kDa; 12 = myosin light chain 1; 13 = 21-18 kDa; 14 = troponin C; 15 = myosin light chain 2; 16 = 14-10 kDa).
mRNA levels of SM22[alpha], Notch[alpha], [alpha]-actin, [alpha]-actinin, caldesmon (Cald), tropomyosin
(Tropom), and myosin light chain kinase (MLCK) in small mesenteric arteries (a) and thoracic aorta (b) from control and obese mice.
ERK: extracellular-signal regulated kinase; HER2: human epidermal growth factor receptor 2; ILT7: immunoglobulin-like transcript 7; NGF: nerve growth factor; PLC: phospholipase C; PTEN: phosphatase and tensin homolog; RhoGEF: Rho guanine nucleotide exchange factor; ROCK: RhoA kinase; TRKA: tropomyosin
receptor kinase A.
Soto, "Nuclear tropomyosin
and troponin in striated muscle: new roles in a new locale?" Journal of Muscle Research and Cell Motility, vol.
Assembly of different isoforms of actin and tropomyosin
into the skeletal tropomyosin-enriched microfilaments during differentiation of muscle cells in vitro.
has acquired from VM Pharma LLC of VM-902A, a first-in-class, allosteric selective tropomyosin
receptor kinase A inhibitor, as well as the backup compounds and associated intellectual property for the potential treatment of chronic pain, the company said.
Both of sarcomeric and cytoplasmic actin filaments are usually associated with tropomyosin
. Tetrahymena actin, which cannot bind rabbit skeletal tropomyosin
, is a rare exception.
receptor kinases (TRKA through TRKC) bind the neurotrophin family of ligands, including nerve growth factor, and have been implicated in tumorigenesis.
The putative heat stable proteins identified were myosin light chain (MLC), actin, tropomyosin
(TPM), troponin T (TnT), myoglobin, and creatine kinase.