Tropomyosin


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tropomyosin

[‚träp·ə′mī·ə·sən]
(biochemistry)
A muscle protein similar to myosin and implicated as being part of the structure of the Z bands separating sarcomeres from each other.

Tropomyosin

 

a protein constituent of muscle myofibrils. Tropomyosin A, or paramyosin, is insoluble in water, in contrast to water-soluble tropomyosin B. Paramyosin is found in the muscles of mollusks and of some arthropods, where it is believed to occupy the center of thick myosin fibers. Tropomyosin B, actin, and myosin are the principal proteins of skeletal muscles and constitute about 11 percent of myofibril protein. Tropomyosin B is a constituent of the thin fibers of I disks (isotropic disks).

References in periodicals archive ?
The symptoms of systemic anaphylaxis were measured before and after tropomyosin challenge and scored based on a scoring system [48]: 0, no symptoms; 1, scratch and rub nose and head; 2, swelling eyes and mouth, diarrhea, slow or no activity with an increased respiratory rate after prodding; 3, wheezing and cyanosis around the mouth and the tail; 4, no activity; and 5, death.
Caption: Figure 3: Densitometric profile and SDS-PAGE of a pool of 15 myofibrillar extracts obtained from beef, lamb, and chicken samples extracted with denaturing (a) and nondenaturing (b) solutions (1 = myosin heavy chain; 2 = 180-110 kDa; 3 = [alpha]-actinin; 4 = 95-55 kDa; 5 = desmin; 6 = 51-47 kDa; 7 = actin; 8 = 39 kDa; 9 = troponin T; 10 = tropomyosin; 11 = 33-23 kDa; 12 = myosin light chain 1; 13 = 21-18 kDa; 14 = troponin C; 15 = myosin light chain 2; 16 = 14-10 kDa).
mRNA levels of SM22[alpha], Notch[alpha], [alpha]-actin, [alpha]-actinin, caldesmon (Cald), tropomyosin (Tropom), and myosin light chain kinase (MLCK) in small mesenteric arteries (a) and thoracic aorta (b) from control and obese mice.
ERK: extracellular-signal regulated kinase; HER2: human epidermal growth factor receptor 2; ILT7: immunoglobulin-like transcript 7; NGF: nerve growth factor; PLC: phospholipase C; PTEN: phosphatase and tensin homolog; RhoGEF: Rho guanine nucleotide exchange factor; ROCK: RhoA kinase; TRKA: tropomyosin receptor kinase A.
Soto, "Nuclear tropomyosin and troponin in striated muscle: new roles in a new locale?" Journal of Muscle Research and Cell Motility, vol.
Assembly of different isoforms of actin and tropomyosin into the skeletal tropomyosin-enriched microfilaments during differentiation of muscle cells in vitro.
IgE cross-reactivity between Ascaris and domestic mite allergens: the role of tropomyosin and the nematode polyprotein ABA-1.
has acquired from VM Pharma LLC of VM-902A, a first-in-class, allosteric selective tropomyosin receptor kinase A inhibitor, as well as the backup compounds and associated intellectual property for the potential treatment of chronic pain, the company said.
Both of sarcomeric and cytoplasmic actin filaments are usually associated with tropomyosin. Tetrahymena actin, which cannot bind rabbit skeletal tropomyosin, is a rare exception.
Tropomyosin receptor kinases (TRKA through TRKC) bind the neurotrophin family of ligands, including nerve growth factor, and have been implicated in tumorigenesis.
The putative heat stable proteins identified were myosin light chain (MLC), actin, tropomyosin (TPM), troponin T (TnT), myoglobin, and creatine kinase.