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Related to Trypanosoma brucei: Trypanosoma cruzi



a genus of protozoans of the class Flagellata that parasitize the blood and tissues of vertebrates, including man. There are several dozen species, many of which are pathogenic. The body is spindle-shaped and has a single nucleus. The flagellum originates in the cytoplasm of the posterior third of the body from the basal corpuscle. It protrudes freely and forms an undulating membrane with the fold of the pellicle. Alongside it is a kinetoplast, a mitochondrion-like organelle that abounds in DNA. Members of the genus reproduce by longitudinal division. There is no sexual process. Most species penetrate into the body of a vertebrate animal or man through transmitters, usually in-sects. The insects either transmit the parasites mechanically with their piercing mouth parts or serve as temporary hosts to the parasites, which reproduce and undergo a succession of morphological changes, becoming crithidiae and leptomonae.

T. gambiense and T. rhodesiense are pathogenic for man; they cause African sleeping sickness, transmitted by flies of the genus Glossina. T. evansi (the causative agent of surra) and T. brucei (the causative agent of nagana) parasitize cattle in Africa and India. In the USSR, camels suffer from su-auru, caused by T. ninaekohlyakimovi, and horses and donkeys suffer from dourine, caused by T. equiperdum.


References in periodicals archive ?
Trypanosoma brucei gambiense type 1 populations from human patients are clonal and display geographical genetic differentiation.
Tests then showed the upgrade - codenamed GNF6702 - could treat Trypanosoma brucei, Trypansosoma cruzi and Leishmania infections in mice.
Cloning and expression of the hypoxanthine-guanine phosphoribosyltransferase gene from Trypanosoma brucei.
Virulence and pathogenicity patterns of Trypanosoma brucei gambiense field isolates in experimentally infected mouse: differences in host immune response modulation by secretome and proteomics.
Trypanosoma brucei parasites, which cause human African trypanosomiasis, also known as sleeping sickness, swim freely in the bloodstream (Vincent and Barrett, 2015).
However, it has been reported that the anaemia caused by the human infective Trypanosoma brucei rhodesiense and Trypanosoma brucei gambiense in rodents ranges between macrocytic normochromic to microcytic hypochromic anaemia [7].
1989) where they obtained excellent growth during the culture of Trypanosoma brucei brucei and T.
Khartoum-26 -6-2013-(SUNA)_ Tsetse fly is a dangerous insect as it carries trypanosoma brucei germ which causes death to cattle and transmits the "Sleeping sickness" to humans , while suspected of causing (Rabies) .
Suppressor macrophages in Trypanosoma brucei infection: nitric oxide is related to both suppressive activity and lifespan in vivo.
Trypanosomiasis occurs in two forms, each caused by a separate subspecies of Trypanosoma brucei T b gambiense or T b rhodesiense.
Human African trypanosomiasis (HAT) cases are caused by the parasites Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense, which are indigenous to west and central Africa.