Trypsinogen


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trypsinogen

[trip′sin·ə·jən]
(biochemistry)
The zymogen of trypsin, secreted in the pancreatic juice. Also known as protrypsin.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Trypsinogen

 

an inactive precursor (proenzyme) of the proteolytic enzyme trypsin. Trypsinogen is synthesized in the pancreas and converted into trypsin—the active enzyme—in the small intestine. The activation of trypsinogen entails the cleavage of a short peptide fragment from the N-terminal of the trypsinogen molecule by the enzyme enterokinase or by trypsin itself.

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
(2011) Intra-acinar trypsinogen activation mediates early stages of pancreatic injury but not inflammation in mice with acute pancreatitis.
Yamamura, "Autophagy and acute pancreatitis: a novel autophagy theory for trypsinogen activation," Autophagy, vol.
Effect of Janus kinase 2/signal transducer and activators of transcription 3 signaling pathway on the release of high mobility group box 1 in trypsinogen activation peptide-induced rat pancreatic acinar cells.
TAP is released, with activation of trypsinogen to trypsin, and plasma and urine levels are known to correlate with severity of pancreatitis.
In a murine model of necrotizing pancreatitis, UTCZP- (CUZD1-) deficient mice developed more severe pancreatitis suggesting that CUZD1 may play an important role in trypsinogen activation and in the severity of pancreatitis [75].
NFAT, and especially the variant NFATc3, were found to regulate the activity of trypsinogen (a precursor form of the digestive enzyme trypsin), which can affect the risk of acute pancreatitis.
It converts trypsinogen to trypsin, indirectly activating a number of pancreatic digestive enzymes.1,2 Enterokinase is a key enzyme for intestinal digestion of proteins.
Screening tests include sweat conductivity measurement and newborn testing for immunoreactive trypsinogen (universal screening is not currently done in South Africa).
Trypsin is secreted as the zymogen trypsinogen; it is converted in the intestine into the active enzyme trypsin by an enzyme called enterokinase.
Cystic fibrosis is one of the conditions included in the screening, and it has two components: measurement of immunoreactive trypsinogen (IRT), an enzyme produced by the pancreas, and if elevated, an assessment of some of the most common genetic mutations causing CF.
Mutations in the gene coding for cationic trypsinogen cause hereditary pancreatitis.
In the animal pancreas, the acinar cells synthesize and store the proteolytic components as inactive precursors such as trypsinogen and chy-motrypsinogen, to protect the gland itself.