(2011) Intra-acinar trypsinogen
activation mediates early stages of pancreatic injury but not inflammation in mice with acute pancreatitis.
Yamamura, "Autophagy and acute pancreatitis: a novel autophagy theory for trypsinogen
activation," Autophagy, vol.
Effect of Janus kinase 2/signal transducer and activators of transcription 3 signaling pathway on the release of high mobility group box 1 in trypsinogen
activation peptide-induced rat pancreatic acinar cells.
TAP is released, with activation of trypsinogen
to trypsin, and plasma and urine levels are known to correlate with severity of pancreatitis.
In a murine model of necrotizing pancreatitis, UTCZP- (CUZD1-) deficient mice developed more severe pancreatitis suggesting that CUZD1 may play an important role in trypsinogen
activation and in the severity of pancreatitis .
NFAT, and especially the variant NFATc3, were found to regulate the activity of trypsinogen
(a precursor form of the digestive enzyme trypsin), which can affect the risk of acute pancreatitis.
It converts trypsinogen
to trypsin, indirectly activating a number of pancreatic digestive enzymes.1,2 Enterokinase is a key enzyme for intestinal digestion of proteins.
Screening tests include sweat conductivity measurement and newborn testing for immunoreactive trypsinogen
(universal screening is not currently done in South Africa).
Trypsin is secreted as the zymogen trypsinogen
; it is converted in the intestine into the active enzyme trypsin by an enzyme called enterokinase.
Cystic fibrosis is one of the conditions included in the screening, and it has two components: measurement of immunoreactive trypsinogen
(IRT), an enzyme produced by the pancreas, and if elevated, an assessment of some of the most common genetic mutations causing CF.
Mutations in the gene coding for cationic trypsinogen
cause hereditary pancreatitis.
In the animal pancreas, the acinar cells synthesize and store the proteolytic components as inactive precursors such as trypsinogen
and chy-motrypsinogen, to protect the gland itself.