tuberculin

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tuberculin

a sterile liquid prepared from cultures of attenuated tubercle bacillus and used in the diagnosis of tuberculosis
Collins Discovery Encyclopedia, 1st edition © HarperCollins Publishers 2005
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Tuberculin

 

a diagnostic agent used to detect an allergic reaction in individuals infected with tubercle bacilli. It was first discovered by R. Koch.

Several types of tuberculin are produced in the USSR, as follows. Liquid tuberculin, or old tuberculin (OT), is prepared by boiling a bouillon culture of tubercle bacilli. Purified protein derivative of tuberculin (PPD) is prepared by adding to a filtrate of bacilli various chemical substances that precipitate proteins, and then purifying the mixture. Liquid purified protein derivative of tuberculin (PPD-L) is prepared by making standard dilutions of purified protein derivative of tuberculin. The tuberculin test detects the presence of tuberculosis; those persons who react positively should then be vaccinated against the disease. The tuberculin test serves as a means of both early diagnosis and of evaluation of the course of tuberculosis. Only the intracutaneous Mantoux test is in wide use in the USSR.

Veterinaries use the tuberculin test to diagnose tuberculosis in animals. The tuberculin is occasionally injected subcutaneously; more commonly, it is injected intracutaneously or into the conjunctival sac. Animals that react positively are considered tuberculotic. A positive reaction is manifested by inflammatory edema after an intracutaneous injection and by purulent conjunctivitis in the eye test.

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.

tuberculin

[tə′bər·kyə·lən]
(immunology)
A preparation containing tuberculoproteins derived from Mycobacterium tuberculosis used in the tuberculin test to determine sensitization to tubercle bacilli.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
The second step consists of 0.1 mL of 5 tuberculin units of PPD, 0.1 ml Candida antigen, and 0.1 mL mumps antigen administered 10-14 days after the first test.
Study nurses then administered 0.1 [cm.sup.3] of RT23 tuberculin intradermally (equivalent to 5 tuberculin units of purified protein derivative -- standard, Mantoux method).
The Mantoux TST is the most accurate test for determining tuberculosis (TB) infection.(1) The standard procedure uses 0.1 cc (5 tuberculin units) of purified protein derivative (PPD) in a standard tuberculin syringe (3/8 inch, 26-27 gauge).
HSCT units should also consider administering a tuberculin skin test (TST) by the Mantoux method with 5 tuberculin units of purified protein derivative (PPD) [CIII]; however, the TST may not be reliable in immunocompromised patients.
Five tuberculin units of purified protein derivative (PPD) tuberculin are injected intradermally with the bevel of the needle pointing upward to form a wheel of 6 to 10 mm.
A positive TST was defined as a reaction of [greater than or equal to]10-mm induration in response to 5 tuberculin units of tuberculin purified protein derivative administered by the Mantoux method,