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Zhou, "Cytocompatibility of electrospun nanofiber tubular scaffolds for small diameter tissue engineering blood vessels," International Journal of Biological Macromolecules, vol.
Zhao, "Cytocompatibility of a silk fibroin tubular scaffold
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In PCL group, one PCL tubular scaffold
(1.5 cm long, 2 mm inner diameter) was implanted in the dorsal subcutaneous space of Balb/c mice .
Using technology developed at Duke and at a spin-off company it started called Humacyte, the vein is engineered by cultivating donated human cells on a tubular scaffold
to form a vessel.
This immersion into a phase separation bath is responsible for the porous structure of the tubular scaffold
, owing to the diffusion of the nonsolvent (water) from the bath to the polymeric solution and of the solvent (dioxane) in the opposite sense.
At the same time, "we hooked this tubular scaffold
to a flow system, which was designed to mimic the actions of the human heart on blood vessels," Niklason explained Within 2 months, the cells had multiplied to cover the scaffolding, which by that time had begun to dissolve.
Citation: Shahab A Shaffiey et al., "Intestinal stem cell growth and differentiation on a tubular scaffold
with evaluation in small and large animals," Regenerative Medicine, 2015; DOI:
Two types of tubular scaffolds
were prepared in ambient conditions.
Electrospinning can be employed to fabricate small-diameter tubular scaffolds
, providing a nanofibrous network structure to mimic the natural arterial ECM.
(b) Tublar porous PLGA scaffolds were prepared by a similar method to collagen scaffolds using a tubular scaffolds