tumor suppressor gene

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tumor suppressor gene

[¦tüm·ər sə′pres·ər jēn]
(cell and molecular biology)
A class of genes which, when mutated, predispose an individual to cancer by causing the loss of function of the particular tumor suppressor protein encoded by the gene.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
Autophagy is required for maintaining cellular homeostasis and has been linked with both protumorigenic and tumor suppression functions [10].
In conclusion, our study demonstrated that IFN[alpha]-AFMSCs are capable of homing to the tumor site in a HeLa cell xenograft model and exhibit therapeutic efficacy in tumor suppression. We also demonstrated that although AF-MSCs alone can selectively engraft into the tumor site and participate in tumor construction, they are safe and effective after being genetically engineered to express IFN[alpha], with the aim of treating cervical cancer.
By studying the role of autophagy-regulating gene, it is evident that autophagy plays a pivotal role in tumor suppression, and defective autophagy or autophagy deficiency leads to tumorigenesis like HCC.
[2] that stated that genotoxic stress may induce a senescent state, which has a role in tumor suppression and is regulated also by p53.
These genes have an important role in tumor suppression. The classic triad of tuberous sclerosis consists of adenoma sebaceum, seizures, and mental retardation, but is only seen in one-third of patients.
"We found that this tumor suppression via adult stem cell quiescence was mediated by Pten, a gene important in regulating the cell's response to signaling pathways," White said, "therefore, stem cell quiescence is a novel form of tumor suppression in hair follicle stem cells, and Pten must be present for the suppression to work."
This has led to a hypothesis that ephrinB2 mediated EphB4 activation and a balanced expression of receptor and ligand lead to tumor suppression [16].
Therefore our mathematical model can be potentially used to examine additional molecular events in tumor suppression [30].
In contrast, a combination of TRAIL, IL-10, and IL-12 can lead to tumor suppression [18].
Karni notes that in a previous study of brain and breast cancer cells with knockdown of hnRNP A2 "we identified key genes of very important pathways involved in cancer development and maintenance," as well as genes that indicate proliferation of cancer or tumor suppression.
Researchers from Case Western Reserve University School of Medicine and Mount Sinai School of Medicine found that the anti-psychotic medication trifluoperazine can reactivate a gene pathway involved in tumor suppression that's normally turned off in lung cancer patients.
(7) Out of the vast array of molecular markers available, markers for tumor growth and those for tumor suppression have been found to have the most prognostic relevance.