A new study showed, for the first time, that tumor-suppressor function can be influenced by phase separation and that mutations in the tumor suppressor
, in this case, SPOP, disrupt phase separation.
Hence, MBD1 might be a tumor suppressor
gene in advanced CRC.
"Therefore, we suggest that COBRA1 displays tumor suppressor
activity and may have a potential role in HCC progression," they said.
* The report provides a snapshot of the global therapeutic landscape for Cellular Tumor Antigen P53 (Tumor Suppressor
P53 or Antigen NY-CO-13)
suggested that PTEN "belongs to a class of 'gatekeeper' tumor suppressor
genes together with p53, Rb, and APC," a notion corroborated by another article published that same year (3), as well as subsequent publications showing that PTEN+I animals develop abroad range of tumors, including mammary, thyroid, endometrial, and prostate cancers as well as T-cell lymphomas.
Kareta et al.; "Inhibition of Pluripotency Networks by the Rb Tumor Suppressor
Restricts Reprogramming and Tumorigenesis"; Cell Stem Cell, 2014; DOI: 10.1016/j.stem.2014.10.019
genes or anti-oncogenes are lost due to chromosomal alterations during tumor formation.
CU-Boulder Professor Min Han said the research team was interested in how a common tumor suppressor
gene known as Retinoblastoma 1, or Rb, behaved under conditions of starvation.
RASSF1A functions as a tumor suppressor
by inhibiting cell proliferation and migration and promoting apoptosis [4, 5, 13].
However, once it is a broad and complex subject, in this work the tumor suppressor
genes will be particularly emphasized, with particular highlight to the p53 gene and protein.
HCC often harbors a TP53 tumor suppressor
gene mutation at codon 249 (R249S).
The P53 tumor suppressor
assay is completed with a battery of protein markers as BCL2, survivin (overexpressed in most breast cancer, BAX- inhibit in 70% of breast cancer), and P21 as novel cancer markers and for prognostic value.