tumor suppressor gene

(redirected from Tumor suppressor)
Also found in: Dictionary, Thesaurus, Medical.
Related to Tumor suppressor: p53, tumor suppressor protein

tumor suppressor gene

[¦tüm·ər sə′pres·ər jēn]
(cell and molecular biology)
A class of genes which, when mutated, predispose an individual to cancer by causing the loss of function of the particular tumor suppressor protein encoded by the gene.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
A new study showed, for the first time, that tumor-suppressor function can be influenced by phase separation and that mutations in the tumor suppressor, in this case, SPOP, disrupt phase separation.
Hence, MBD1 might be a tumor suppressor gene in advanced CRC.
"Therefore, we suggest that COBRA1 displays tumor suppressor activity and may have a potential role in HCC progression," they said.
* The report provides a snapshot of the global therapeutic landscape for Cellular Tumor Antigen P53 (Tumor Suppressor P53 or Antigen NY-CO-13)
suggested that PTEN "belongs to a class of 'gatekeeper' tumor suppressor genes together with p53, Rb, and APC," a notion corroborated by another article published that same year (3), as well as subsequent publications showing that PTEN+I animals develop abroad range of tumors, including mammary, thyroid, endometrial, and prostate cancers as well as T-cell lymphomas.
Kareta et al.; "Inhibition of Pluripotency Networks by the Rb Tumor Suppressor Restricts Reprogramming and Tumorigenesis"; Cell Stem Cell, 2014; DOI: 10.1016/j.stem.2014.10.019
Tumor suppressor genes or anti-oncogenes are lost due to chromosomal alterations during tumor formation.
CU-Boulder Professor Min Han said the research team was interested in how a common tumor suppressor gene known as Retinoblastoma 1, or Rb, behaved under conditions of starvation.
RASSF1A functions as a tumor suppressor by inhibiting cell proliferation and migration and promoting apoptosis [4, 5, 13].
However, once it is a broad and complex subject, in this work the tumor suppressor genes will be particularly emphasized, with particular highlight to the p53 gene and protein.
HCC often harbors a TP53 tumor suppressor gene mutation at codon 249 (R249S).
The P53 tumor suppressor assay is completed with a battery of protein markers as BCL2, survivin (overexpressed in most breast cancer, BAX- inhibit in 70% of breast cancer), and P21 as novel cancer markers and for prognostic value.