tumor suppressor gene

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tumor suppressor gene

[¦tüm·ər sə′pres·ər jēn]
(cell and molecular biology)
A class of genes which, when mutated, predispose an individual to cancer by causing the loss of function of the particular tumor suppressor protein encoded by the gene.
References in periodicals archive ?
A total of 1217 known tumor suppressor genes was searched from the tumor suppressor gene database (TSGene 2.0) [8, 9].
Mutation of p53 allows tumours Gl-S boundary, propagate genetic alterations which can lead to other activated oncogenes or inactivated tumor suppressor genes. Alteration of the p53 gene occurs as point mutations and deletions.
When researchers checked to see if any of the CYCLOPS genes were neighbors of missing tumor suppressor genes, as Frei had hypothesized two decades earlier, they found that, indeed, many were.
Tumor suppressor genes are divided into two classes, the caretaker genes and the gatekeeper genes, according to the role they play.
Since the presence of CpG island hypermethylation of the tumor suppressor genes described is specific to transformed cells.
This region contains the Lung Cancer Tumor Suppressor Gene Region 1 (LCTSGR1), where genes as RASSF1A, HYAL2/LUCA, FUS1/TUSC2,101F6/CYB561D2, and CPR2L/CPRL2/ TUSC4, are located.
Identification of the von Hippel-Lindau disease tumor suppressor gene. Science.
Tumor suppressor genes play an important role in regulating the cell cycle and normal cell behavior.
Inactivation of one of these tumor suppressor genes is involved in many malignant tumors, and in some studies a negative correlation of p16 and Rb expression has been found.
These affect both proto-oncogenes and tumor suppressor genes. Two "bits" are needed for inactivation of tumor suppressor genes; the first is often a point mutation, either germ line or somatic.
Parker, Introgen's senior vice president of Intellectual Property said, "This patent is of particular importance in that it provides protection for the systemic delivery of tumor suppressor genes such as p53, mda-7 and numerous others, by using synthetic nanoparticles.
This may lead directly to the identification of tumor suppressor genes or can be used as a prognostic and diagnostic tool to characterize known tumor suppressor genes.