tumor suppressor gene

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Related to Tumor suppressor proteins: TP53

tumor suppressor gene

[¦tüm·ər sə′pres·ər jēn]
(cell and molecular biology)
A class of genes which, when mutated, predispose an individual to cancer by causing the loss of function of the particular tumor suppressor protein encoded by the gene.
References in periodicals archive ?
We believe our study to be the first to concomitantly examine the expression of more than 2 tumor suppressor proteins in the same series of pediatric EFTs.
David Livingston, where he began his studies of tumor suppressor proteins.
Selinexor functions by binding to the nuclear export protein XPO1 (also called CRM1), leading to the accumulation of tumor suppressor proteins in the cell nucleus, which subsequently reinitiates and amplifies their tumor suppressor function.
Velcade is also known to prolong expression of other tumor suppressor proteins such as p53.