tumor suppressor gene

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Related to Tumor suppressor proteins: TP53

tumor suppressor gene

[¦tüm·ər sə′pres·ər jēn]
(cell and molecular biology)
A class of genes which, when mutated, predispose an individual to cancer by causing the loss of function of the particular tumor suppressor protein encoded by the gene.
References in periodicals archive ?
Results from this study indicates the activation of tumor suppressor proteins such as p27 and RB1 coherently triggered with suppressor oncogene proteins such as SKP2 and BLC2
HPV promotes cervical cancer primarily by attacking the tumor suppressor proteins p53 and pRb.
Cisplatin's suppressive action involves a different pathway through the tumor suppressor proteins p16 and p53, both proteins that again inhibit the activity of cancer growth promoter NF?B.
We believe our study to be the first to concomitantly examine the expression of more than 2 tumor suppressor proteins in the same series of pediatric EFTs.

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