tumor suppressor gene

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Related to Tumor suppressor proteins: TP53

tumor suppressor gene

[¦tüm·ər sə′pres·ər jēn]
(cell and molecular biology)
A class of genes which, when mutated, predispose an individual to cancer by causing the loss of function of the particular tumor suppressor protein encoded by the gene.
References in periodicals archive ?
Twelve cases (60%) demonstrated abnormal expression of at least one tumor suppressor protein (Table 2).
Dilara McCauley of Karyopharm will present "Selective inhibitors of nuclear export (SINE) induce multiple tumor suppressor proteins (TSP) activity and show single agent antitumor effect and synergy with Bcl-2 antagonist in non-small cell lung cancer" (Abstract 1831; Section 30).
Other components, called p21 and cyclins, are tumor suppressor proteins that help block DNA synthesis as cells divide.
inappropriate removal of vital tumor suppressor proteins, such as p53
Projects at The University of Texas Health Science Center Houston Medical School include studies of processing of tumor suppressor proteins involved in nuclear regulation in colon cancer, proteomic analysis of phosphoproteins involved in immuno-suppressive disorders, and proteomic analysis of nitrosylated proteins involved in renal and cardiovascular disease.
For example, many cancers are caused by the excess removal of tumor suppressor proteins, such as p53 and p27, that results in cancer cell proliferation.