Tyramine


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tyramine

[′tī·rə‚mēn]
(pharmacology)
HOC6H4CH2CH2NH2 A crystalline compound with a melting point of 164-165°C; soluble in water and boiling alcohol; used in medicine as an adrenergic drug. Also known as tyrosamine.

Tyramine

 

(4-hydroxyphenylethylamine; HOC6H4CH2CH2NH2), an organic substance; one of the biogenic amines.

Tyramine is found in ergot, decaying tissues, and cheese. A toxic substance, tyramine is physiologically active: because of its vasoconstrictor effect, it increases blood pressure and influences processes of excitation and inhibition in the nervous system. It is formed from the amino acid tyrosine under the action of bacterial decarboxylases, particularly in the case of putrefactive processes in the intestines of humans and other mammals. Excess tyramine in the body is rendered harmless through oxidation by monoamine oxidase.

REFERENCE

Gorkin, V. Z. “Fermentativnoe dezaminirovanie biogennykh aminov.” In Khimicheskie faktory reguliatsii aktivnosti i biosinteza fermentov. Moscow, 1969.
References in periodicals archive ?
The second variable corresponds to HPLC quantification of biogenic amines (histamine, tyramine, putrescine, cadaverine and phenylethylamine)
Tyramine is one kind of monoamine, also known as 2-(4-hydroxyphenyl) ethylamine which occurs naturally in cheese and other foods.
The eight studied amines were putrescine (PUT), cadaverine (CAD), histamine (HIM), tyramine (TYM), serotonin (SRT), agmatine (AGM), spermidine (SPD) and phenylethylamine (PEM).
Tyramine and 2-phenylethylamine were only found in group B2 with very low amount of 0.3 [micro]g/g.
Tyramine and guaiacol are metabolic products of tyrosine, which is closely related to the synthesis of catecholamine.
In vitro, transduction of cardiomyocytes with a MAO-A adenovirus in the presence of tyramine reproduced mitochondrial damage, diminished ATP production, and decreased PGC-1a expression and necrosis through ROS generation.
Names: doxycycline, tetracycline (MAOIs) Antidepressants- Foods that contain high Monoamine Oxidase Inhibitors: amounts of tyramine can spike Treat depression by balancing blood pressure.
Amine compounds were identified and quantified based on comparison with standard curves constructed from pure compounds (histamine, methylamine, ethylamine and tyramine).
The most common biogenic amines found in foods are histamine, tyramine, cadaverine, 2-phenylethylamine, spermine, sperm idi ne, putrescine, tryptamine, and agmatine.
Although no information in Brazilian legislation on the safe levels of bioactive amines ingestion is available, it is already known that the consumption of great amounts of histamine, tyramine and phenylethylamine may have toxic effects on humans.
Formation of histamine and tyramine by some lactic acid bacteria in MRS broth and modified decarboxylation agar.