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An enzyme found in plants, molds, crustaceans, mollusks, and some bacteria which, in the presence of oxygen, catalyzes the oxidation of monophenols and polyphenols with the introduction of ‒OH groups and the formation of quinones.



(ortho-diphenoloxidase), a enzyme of the oxidoreductase class that is present in almost all animals and plants. Tyrosinase catalyzes the oxidation of the amino acid tyrosine into dopa during the biosynthesis of melanins. It takes part in the synthesis of epinephrine and in other metabolic processes. Hereditary disruption of tyrosinase activity or the absence of tyrosinase causes albinism. Tyrosinase has been found to be identical to polyphenoloxidase.

References in periodicals archive ?
Like Rumex occidentalis, alpha-arbutin possesses strong inhibitory effects on tyrosinase.
As to tyrosinase inhibitor effects, the best inhibitory effect were observed in T-Me and F-W found to be inactive against tyrosinase.
Quantification of tyrosinase, TRP-1 and TRP-2 transcripts in human melanocytes by reverse transcriptase-competitive multiplex PCR--regulation by steroid hormones.
Antibodies used in this study are the following: p-CREB (SC-101663), tyrosinase (SC-15341), MITF (SC-11002), MMP1 (SC-12348), MMP9 (SC-6840), MMP12 (sC-30072) MMP13 (SC-12363), type 1 procollagen (SC-25973), type 3 procollagen (SC-8779), p-p65 (S536) (SC-33020), iNOS (SC-8310), [beta]-actin (SC-47778), and TFIIB (SC-225).
It stops tyrosinase activity better than arbutin and Kojic acid, but it is more effective when combined with other agents like retinoids.
As a member of the Na+/H+ antiporter family the OCA2 protein is thought to play an essential role in maintaining the acid pH of the melanosomes which regulates the tyrosinase activity.
2013) Isolation of long-chain esters from the rhizome of Polygonatum verticillatum by potent tyrosinase inhibition.
The tyrosinase, encoded by tyrosinase (TYR) gene, is known to be the rate-limiting enzyme affecting the production of melanin pigment (Sanchez-Ferrer et al.
In addition, some authors have described a cross-reactive T cell response between tyrosinase peptides and the CMV antigen in VKH patients.
Melanin is produced in the skin by the melanocytes through a series of oxidative reactions involving the amino acid tyrosine and the enzyme tyrosinase.
The Merial vaccine uses human DNA to trigger a dog's immune system to detect one antigen (protein) found in melanoma cells--the protein tyrosinase, which contributes to dark pigmentation.