tyrosine hydroxylase


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Related to tyrosine hydroxylase: DOPA decarboxylase

tyrosine hydroxylase

[‚tī·rə‚sēn hī′dräk·sə‚lās]
(biochemistry)
A specialized enzyme located only in catecholamine-containing nerve cells, where it serves as the primary regulatory or rate-limiting step in catecholamine biosynthesis.
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References in periodicals archive ?
Salvatore, "Exercise-mediated increase in nigral tyrosine hydroxylase is accompanied by increased nigral GFR-[alpha]1 and EAAC1 expression in aging rats," ACS Chemical Neuroscience, vol.
In addition, although PAS treatment did not improve other parameters, the positive effects observed in catalepsy behavior and tyrosine hydroxylase expression are relevant because they suggest a potential delay in the neurodegeneration caused by PD.
We thank Arthur Tischler, MD, for assistance in performing the tyrosine hydroxylase immunohistochemical stain, and Patricia Dahia, MD, PhD, for assistance with the succinate dehydrogenase B immunohistochemical stain and for reviewing the manuscript.
Besides, the immunohistochemical analysis for tyrosine hydroxylase (TH) positive neurons indicated that 6-OHDA caused a concentration-dependent loss of TH+ and TH- neurons.
Tyrosine hydroxylase: the initial step in norepinephrine biosynthesis.
Geller, "Long-term behavioral recovery in parkinsonian rats by an HSV vector expressing tyrosine hydroxylase," Science, vol.
Joh, "Transneuronal regulation of tyrosine hydroxylase expression in olfactory bulb of mouse and rat," Journal of Neuroscience, vol.
found that Clock mice had increased levels of tyrosine hydroxylase in the VTA.
Tyrosine hydroxylase immunoreactive cells (THir cells) were counted in 40 adjoining fields (2.8 [mm.sup.2]/field)/well.
pale encodes the enzyme tyrosine hydroxylase (TH) that catalyzes the conversion of tyrosine to dopa and ddc encodes dopa decarboxylase (DDC) that is responsible for the conversion of dopa to dopamine (Sugumaran, 1988).
Histological and immunohistochemical procedures: Four treated animals were sacrificed either 5 or 15 days following surgery for detection of SSEA1 antigen or tyrosine hydroxylase (TH).